Description

(4-(Trifluoromethyl)phenyl)magnesium bromide (CAS No. 402-51-7) is a highly reactive Grignard reagent with the molecular formula C₇H₄BrF₃Mg. This organomagnesium compound is widely utilized in synthetic organic chemistry for the introduction of the 4-(trifluoromethyl)phenyl group into target molecules. Supplied as a solution in diethyl ether or tetrahydrofuran (THF), it offers excellent reactivity in nucleophilic addition reactions, coupling reactions, and as a precursor for further functionalization. Ideal for researchers in pharmaceuticals, agrochemicals, and materials science, this reagent is handled under inert conditions to ensure stability and purity. Each batch is rigorously tested for concentration and quality, making it a reliable choice for demanding synthetic applications.

Properties

• CAS Number: 402-51-7
• Complexity: 199
• IUPAC Name: magnesium;trifluoromethylbenzene;bromide
• InChI: InChI=1S/C7H4F3.BrH.Mg/c8-7(9,10)6-4-2-1-3-5-6;;/h2-5H;1H;/q-1;;+2/p-1
• InChI Key: HTUYHICLOWMUIN-UHFFFAOYSA-M
• Exact Mass: 247.92989
• Molecular Formula: C7H4BrF3Mg
• Molecular Weight: 249.31
• SMILES: C1=CC(=CC=[C-]1)C(F)(F)F.[Mg+2].[Br-]
• Monoisotopic Mass: 247.92989
• Synonyms: 402-51-7, (4-(trifluoromethyl)phenyl)magnesium bromide, magnesium;trifluoromethylbenzene;bromide, bromo[4-(trifluoromethyl)phenyl]magnesium, 4-TRIFLUOROMETHYLPHENYLMAGNESIUMBROMIDE, (4-(Trifluoromethyl)phenyl)magnesium bromide, 0.50 M in 2-MeTHF, [4-(trifluoromethyl)phenyl]magnesium bromide, SCHEMBL624840, IPMRFNJFZBOIKO-UHFFFAOYSA-M, DTXSID801271735, p-Trifluormethyl-phenyl-magnesiumbromid, 4-trifluoromethylphenylmagnesium bromide, (4-Trifluoromethylphenyl)magnesium bromide, 4-(trifluoromethyl)phenylmagnesium bromide, 4-(trifluormethyl)-phenylmagnesium bromide, bromo[4-(trifluoro-methyl)phenyl]magnesium, 4-(trifluoro-methyl)phenylmagnesium bromide, (4-(Trifluoromethyl)phenyl)magnesium bromide, 0.50 M in THF, (4-(Trifluoromethyl)phenyl)magnesium bromide (1M solution in Diethyl ether), (4-(Trifluoromethyl)phenyl)magnesium bromide, 0.25 M in THF 0.25 M in THF

Application

(4-(Trifluoromethyl)phenyl)magnesium bromide is primarily used in organic synthesis as a nucleophilic reagent for the formation of carbon-carbon bonds. It is particularly valuable in the preparation of trifluoromethyl-substituted aromatic compounds, which are important in pharmaceutical and agrochemical development. The reagent is also employed in cross-coupling reactions to synthesize complex organic molecules. Its high reactivity makes it suitable for creating intermediates in drug discovery and material science applications.

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