Description

4-(Trifluoromethyl)diphenyl ether (CAS No. 2367-02-4) is a high-purity fluorinated aromatic ether compound with the molecular formula C₁₃H₉F₃O. This specialty chemical is characterized by its trifluoromethyl (-CF₃) functional group attached to a diphenyl ether backbone, offering unique electronic and steric properties for advanced research applications. It is supplied as a clear, colorless to pale yellow liquid with a typical purity of ≥98% (GC), ensuring consistency for synthetic and material science applications. Suitable for use as a building block in pharmaceuticals, agrochemicals, and liquid crystal materials. Store under inert atmosphere at 2-8°C to maintain stability. Available in research quantities (100mg to 10kg) with optional analytical certificates.

Properties

• CAS Number: 2367-02-4
• Complexity: 225
• IUPAC Name: 1-phenoxy-4-(trifluoromethyl)benzene
• InChI: InChI=1S/C13H9F3O/c14-13(15,16)10-6-8-12(9-7-10)17-11-4-2-1-3-5-11/h1-9H
• InChI Key: UZJUDUZMPNCXPF-UHFFFAOYSA-N
• Exact Mass: 238.06054939
• Molecular Formula: C13H9F3O
• Molecular Weight: 238.20
• SMILES: C1=CC=C(C=C1)OC2=CC=C(C=C2)C(F)(F)F
• Topological: 9.2
• Monoisotopic Mass: 238.06054939
• Synonyms: 2367-02-4, 4-(Trifluoromethyl)diphenyl ether, DTXSID30380544, DTXCID70331570, 1-phenoxy-4-(trifluoromethyl)benzene, 4-Phenoxybenzotrifluoride, Benzene, 1-phenoxy-4-(trifluoromethyl)-, 4-(Trifluoromethyl)diphenylether, 4-phenoxy-1-(trifluoromethyl)benzene, MFCD01631641, trifluoromethyldiphenyl ether, SCHEMBL254896, SCHEMBL455068, SCHEMBL921675, SCHEMBL5543276, SCHEMBL5903450, SCHEMBL5903663, UZJUDUZMPNCXPF-UHFFFAOYSA-N, SBB098920, AKOS015995332, AS-40446, DB-046214, CS-0156087, ST50407423

Application

4-(Trifluoromethyl)diphenyl ether serves as a versatile intermediate in organic synthesis, particularly for introducing trifluoromethyl groups into complex molecules. Researchers utilize this compound in the development of pharmaceutical candidates due to the metabolic stability imparted by the CF₃ moiety. In materials science, it finds application as a precursor for liquid crystal compounds and dielectric materials. The electron-withdrawing nature of the trifluoromethyl group makes it valuable for tuning electronic properties in conjugated systems.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.