Description

4-(Trifluoromethoxy)fluorobenzene (CAS No. 352-67-0) is a high-purity fluorinated aromatic compound with the molecular formula C₇H₄F₄O. This specialty chemical, also known by its IUPAC name 1-fluoro-4-(trifluoromethoxy)benzene, features a benzene ring substituted with both a fluorine atom and a trifluoromethoxy group at the para position, enhancing its electron-withdrawing properties. Ideal for advanced research and industrial applications, this compound exhibits exceptional thermal and chemical stability, making it suitable for use in demanding environments. Available in rigorously controlled batches, our product is characterized by GC purity ≥98%, ensuring consistency for synthetic, pharmaceutical, and material science applications. Packaged under inert gas to preserve integrity, it is supplied in amber glass bottles or custom bulk quantities.

Properties

• CAS Number: 352-67-0
• Complexity: 137
• IUPAC Name: 1-fluoro-4-(trifluoromethoxy)benzene
• InChI: InChI=1S/C7H4F4O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4H
• InChI Key: JULMJGDXANEQDP-UHFFFAOYSA-N
• Exact Mass: 180.01982740
• Molecular Formula: C7H4F4O
• Molecular Weight: 180.10
• SMILES: C1=CC(=CC=C1OC(F)(F)F)F
• Topological: 9.2
• Monoisotopic Mass: 180.01982740
• Synonyms: 1-Fluoro-4-(trifluoromethoxy)Benzene, 352-67-0, 4-(Trifluoromethoxy)fluorobenzene, Benzene, 1-fluoro-4-(trifluoromethoxy)-, p,alpha,alpha,alpha-Tetrafluoroanisole, GY6RDC3FBT, EINECS 206-523-2, DTXSID40188699, ANISOLE, P,.ALPHA.,.ALPHA.,.ALPHA.-TETRAFLUORO-, DTXCID50111190, ANISOLE, P,ALPHA,ALPHA,ALPHA-TETRAFLUORO-, 206-523-2, 4-FLUORO(TRIFLUOROMETHOXY)BENZENE, p-Fluorophenyl trifluoromethyl ether, 1-Fluoro-4-trifluoromethoxy-benzene, trifluoro(4-fluorophenoxy)methane, MFCD00040835, UNII-GY6RDC3FBT, p,A,A,A-Tetrafluoroanisole, p-fluorotrifluoromethoxybenzene, SCHEMBL255560, SCHEMBL900639, SCHEMBL900873, SBB089613, AKOS005064101, 4-Fluorophenyl trifluoromethyl ether #, CS-W017232, 1-fluoro-4-(trifluoromethyloxy)-benzene, AC-26093, PS-11655, DB-023923, NS00042106, ST50407115, EN300-305770, 4-Fluorophenyl trifluoromethyl ether;p-(Trifluoromethoxy)fluorobenzene

Application

4-(Trifluoromethoxy)fluorobenzene serves as a versatile building block in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals due to its electron-deficient aromatic core. It is employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce fluorinated motifs into target molecules, enhancing metabolic stability and lipophilicity. Researchers also utilize it in material science for designing liquid crystals and high-performance polymers with tailored dielectric properties.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H315 (97.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Skin Irrit. 2 (97.8%)
• Eye Irrit. 2A (97.8%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.