Description

4-(Trifluoromethoxy)benzylamine (CAS No. 93919-56-3) is a high-purity organic compound with the molecular formula C₈H₈F₃NO. This specialized chemical features a benzylamine core substituted with a trifluoromethoxy group at the para position, enhancing its reactivity and utility in synthetic chemistry. It is widely used as a versatile building block in pharmaceuticals, agrochemicals, and advanced material science due to its electron-withdrawing trifluoromethoxy group, which improves metabolic stability and bioavailability. Available in ≥95% purity, this product is rigorously tested via HPLC, GC, and NMR to ensure compliance with research and industrial standards. Suitable for laboratory and commercial-scale applications, it is packaged under inert conditions to maintain stability and shelf life.

Properties

• CAS Number: 93919-56-3
• Complexity: 152
• IUPAC Name: [4-(trifluoromethoxy)phenyl]methanamine
• InChI: InChI=1S/C8H8F3NO/c9-8(10,11)13-7-3-1-6(5-12)2-4-7/h1-4H,5,12H2
• InChI Key: DBGROTRFYBSUTR-UHFFFAOYSA-N
• Exact Mass: 191.05579836
• Molecular Formula: C8H8F3NO
• Molecular Weight: 191.15
• SMILES: C1=CC(=CC=C1CN)OC(F)(F)F
• Topological: 35.3
• Monoisotopic Mass: 191.05579836
• Synonyms: 4-(Trifluoromethoxy)benzylamine, 93919-56-3, EINECS 300-040-1, DTXSID20239895, DTXCID70162386, 300-040-1, (4-(trifluoromethoxy)phenyl)methanamine, [4-(Trifluoromethoxy)phenyl]methanamine, 1-[4-(trifluoromethoxy)phenyl]methanamine, 4-(trifluoromethoxy)benzyl amine, MFCD00061237, Benzenemethanamine, 4-(trifluoromethoxy)-, 4-trifluoromethoxybenzylamine, [4-(trifluoromethoxy)phenyl]methylamine, EN300-25596, p-trifluoromethoxybenzylamine, 4trifluoromethoxy-benzylamine, 4-trifluormethoxy-benzylamine, 4-trifluoromethoxy benzylamine, 4-trifluoromethoxy-benzylamine, 4-trifluoromethoxybenzyl amine, SCHEMBL106741, 4-trifluoromethoxy-benzyl amine, CHEMBL216733, SCHEMBL1352897, SCHEMBL3861141, 4-(trifluormethoxy)-benzylamine, SCHEMBL27859894, 4-(trifluoromethoxy)-benzylamine, [4-(trifluoromethoxy)benzyl]amine, QKEQESHKCJUQDA-UHFFFAOYSA-N, BDBM626121, ALBB-006030, (4-trifluoromethoxyphenyl)methanamine, CK1122, SBB048032, STK503677, 4-(Trifluoromethoxy)benzylamine, 95%, AKOS000264340, AC-2348, CS-W013220, FS-1027, P-(TRIFLUOROMETHOXY)BENZYL AMINE, SY016916, [4-(Trifluoromethoxy)phenyl]methanamine #, DB-057449, NS00064264, ST50405155, Q27452013, F2145-0705, Z212046238, 1FD

4-(Trifluoromethoxy)benzylamine serves as a key intermediate in the synthesis of bioactive molecules, particularly in drug discovery for CNS and antiviral agents. Its trifluoromethoxy group enhances lipophilicity, making it valuable for optimizing pharmacokinetic properties. Commonly employed in peptide coupling reactions and as a precursor for heterocyclic compounds, it is also utilized in agrochemical formulations to improve pesticide efficacy. Researchers leverage its stability under acidic conditions for catalysis and polymer modification.

Safety and Hazards

GHS Hazard Statements

• H314 (15.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (84.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (84.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (89.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (15.2%)
• Skin Irrit. 2 (84.8%)
• Eye Irrit. 2 (84.8%)
• STOT SE 3 (89.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.