Description

4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS No. 214360-73-3) is a high-purity boronic ester derivative with the molecular formula C₁₂H₁₈BNO₂. This compound, also known as 4-Aminophenylboronic acid pinacol ester, features a stable pinacol boronate group attached to an aniline moiety, making it a versatile building block in organic synthesis and pharmaceutical research. Its crystalline solid form and excellent solubility in common organic solvents ensure ease of handling and reactivity. Ideal for Suzuki-Miyaura cross-coupling reactions, this reagent is rigorously tested for quality (≥95% purity by HPLC) and is packaged under inert conditions to guarantee stability. Suitable for researchers in medicinal chemistry, material science, and catalysis.

Properties

• CAS Number: 214360-73-3
• Complexity: 244
• IUPAC Name: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
• InChI: InChI=1S/C12H18BNO2/c1-11(2)12(3,4)16-13(15-11)9-5-7-10(14)8-6-9/h5-8H,14H2,1-4H3
• InChI Key: ZANPJXNYBVVNSD-UHFFFAOYSA-N
• Exact Mass: 219.1430590
• Molecular Formula: C12H18BNO2
• Molecular Weight: 219.09
• SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC=C(C=C2)N
• Topological: 44.5
• Monoisotopic Mass: 219.1430590
• Synonyms: 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, 629-061-7, 214360-73-3, 4-Aminophenylboronic acid pinacol ester, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, 4-Aminophenylboronic acid, pinacol ester, (4-aminophenyl)boronic acid pinacol ester, 4-aminophenylboronic acid pinacolate, MFCD02093721, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine, 4-aminobenzeneboronic acid pinacol ester, 4-aminobenzeneboronic acid, pinacol ester, 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYLAMINE, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-aniline, [4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]amine, (4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 2-(4-Aminophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzeneamine; 4-Aminophenylboronic Acid Pinacol Ester, Pinacol cyclic ester, BENZENAMINE, 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-, SCHEMBL55445, SCHEMBL28603305, 4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)aniline, DTXSID30370400, 4-aminophenyl boronic pinacol ester, BCP03638, CS-M0336, BBL100653, RB3075, STL554447, AKOS005255073, AC-6954, AS-2605, FA55450, PB19964, 4-aminophenyl boronic acid pinacol ester, 4-Aminophenylboronic acid pinacol ester, NCGC00662663-01, HY-75597, PD131306, SY002377, DB-005312, T1951, 4-Aminophenylboronic acid pinacol ester, 97%, EN300-175989, 4-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)aniline, F0001-6432, Z1509382214, 1-hydroperoxy-8-carboxyoctyl-3,4-epoxynon-(2E)-enyl-ether, 4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)aniline, 4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, 4-(4,4,5,5-tetramethyl 1,3,2 dioxaborolan-2-yl) aniline, 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-aniline, 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline, 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxa-borolan-2-yl)aniline, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) aniline, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzenamine, 4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenylamine, 4-(4,4,5,5-tetramethyl[1.3.2]dioxaborolan-2-yl)phenylamine, 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine

Application

4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is widely used as a key intermediate in Suzuki-Miyaura cross-coupling reactions to synthesize biaryl compounds for pharmaceuticals and agrochemicals. Its aniline group allows further functionalization, enabling the development of dyes, sensors, and advanced materials. The compound’s stability and reactivity also make it valuable in peptide modification and boron neutron capture therapy (BNCT) research.

Safety and Hazards

GHS Hazard Statements

• H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (97.9%)
• Eye Irrit. 2 (97.9%)
• STOT SE 3 (95.7%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.