Description

4-tert-Butylphenylboronic acid (CAS No. 123324-71-0) is a high-purity boronic acid derivative with the molecular formula C₁₀H₁₅BO₂. This organoboron compound is widely utilized in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, due to its excellent reactivity and stability. The presence of the tert-butyl group enhances its steric and electronic properties, making it a valuable reagent for constructing complex aromatic frameworks. Ideal for pharmaceutical, agrochemical, and materials science research, our product is rigorously tested to ensure ≥95% purity (HPLC) and is supplied as a white to off-white crystalline powder. Store in a cool, dry place under inert conditions to maintain optimal stability.

Properties

• CAS Number: 123324-71-0
• Complexity: 155
• IUPAC Name: (4-tert-butylphenyl)boronic acid
• InChI: InChI=1S/C10H15BO2/c1-10(2,3)8-4-6-9(7-5-8)11(12)13/h4-7,12-13H,1-3H3
• InChI Key: MNJYZNVROSZZQC-UHFFFAOYSA-N
• Exact Mass: 178.1165099
• Molecular Formula: C10H15BO2
• Molecular Weight: 178.04
• SMILES: B(C1=CC=C(C=C1)C(C)(C)C)(O)O
• Topological: 40.5
• Monoisotopic Mass: 178.1165099
• Synonyms: 4-tert-Butylphenylboronic acid, 123324-71-0, (4-tert-butylphenyl)boronic Acid, DTXSID60370211, DTXCID00321247, 602-928-7, (4-(tert-Butyl)phenyl)boronic acid, 4-t-butylphenylboronic acid, 4-tert-Butylbenzeneboronic Acid, MFCD01009697, Boronic acid, B-[4-(1,1-dimethylethyl)phenyl]-, 4-tert-Butylphenyl boronic acid, 4-tert-butyl-phenyl boronic acid, 4-(tert-butyl)phenylboronic acid, 4-(tert-butyl)benzeneboronic acid, Boronic acid, [4-(1,1-dimethylethyl)phenyl]-, p-t-butylphenylboronic acid, 4-tertbutylphenylboronic acid, SCHEMBL27736, 4-t-butylphenyl boronic acid, 4-t-butylphenyl-boronic acid, 4-t-butyl phenyl boronic acid, 4-t-butyl-phenyl boronic acid, 4-tert-butyl-phenylboronic acid, 4-tert-butyl-benzeneboronic acid, (4-tert-butyl)phenylboronic acid, 4-(tertbutyl)-phenylboronic acid, 4-tert-butyl phenyl boronic acid, 4-tert-butyl-phenyl-boronic acid, 4-tert-butyl benzene boronic acid, 4-tert-butyl-benzene boronic acid, 4-(tert-butyl)-phenylboronic acid, BCP22766, STR03834, 4-(tert butyl)-phenyl boronic acid, 4-tert-Butylphenylboronic acid (contains varying amounts of Anhydride), SBB089356, AKOS003585337, AB07967, AC-5365, BCP9000169, CS-W007389, FB55389, HY-W007389, NCGC00249512-01, SY001215, 4-tert-Butylphenylboronic acid, >=95.0%, DB-009552, B2251, EN300-49217, [4-(1,1-DIMETHYLETHYL)PHENYL]BORONIC ACID, Z330828692, 4-tert-Butylbenzeneboronic acid; 4-(tert-Butyl)phenylboronic acid

Application

4-tert-Butylphenylboronic acid is a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the synthesis of biaryl compounds for pharmaceuticals and advanced materials. It is also employed in the development of sensors and catalysts due to its boronic acid functionality. Researchers leverage its sterically hindered structure to study steric effects in organic transformations.

Safety and Hazards

GHS Hazard Statements

• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (88.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (88.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.