Description

4-Phenylbenzoyl chloride (CAS 14002-51-8) is a high-purity aromatic acyl chloride with the molecular formula C₁₃H₉ClO. This compound, also known as [1,1′-Biphenyl]-4-carbonyl chloride, is a versatile reagent widely used in organic synthesis, particularly in the formation of amides, esters, and other derivatives via nucleophilic acyl substitution reactions. Its biphenyl structure enhances reactivity and stability, making it valuable for pharmaceutical intermediates, liquid crystal materials, and advanced polymer applications. Available in rigorously controlled batches, our 4-Phenylbenzoyl chloride meets stringent quality standards for research and industrial use, ensuring optimal performance in sensitive synthetic workflows. Packaged under inert conditions to prevent hydrolysis, this product is ideal for demanding laboratory and production environments.

Properties

• CAS Number: 14002-51-8
• Complexity: 213
• IUPAC Name: 4-phenylbenzoyl chloride
• InChI: InChI=1S/C13H9ClO/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H
• InChI Key: JPVUWCPKMYXOKW-UHFFFAOYSA-N
• Exact Mass: 216.0341926
• Molecular Formula: C13H9ClO
• Molecular Weight: 216.66
• SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)Cl
• Topological: 17.1
• Monoisotopic Mass: 216.0341926
• Synonyms: 4-Biphenylcarbonyl chloride, 4-Phenylbenzoyl chloride, p-Phenylbenzoyl chloride, [1,1′-Biphenyl]-4-carbonyl chloride, (1,1′-Biphenyl)-4-carbonyl chloride, UNII-6QS928042D, EINECS 237-804-8, 6QS928042D, DTXSID5065693, JPVUWCPKMYXOKW-UHFFFAOYSA-, Diphenyl-4-carboxylic acid chloride, BIPHENYLCARBONYLCHLORIDE, 4-, DTXCID6034550, inchi=1/c13h9clo/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9h, jpvuwcpkmyxokw-uhfffaoysa-n, 14002-51-8, Biphenyl-4-carbonyl chloride, 4-phenyl benzoyl chloride, MFCD00000692, 4-phenylbenzoylchloride, p-Biphenylcarbonyl chloride, [1,1′-biphenyl)-4carbonyl chloride, [1,1′-biphenyl]-4carbonyl chloride, p-phenyl benzoyl chloride, 4-Biphenylcarbonylchloride, 4-phenyl-benzoyl chloride, 4-biphenyl carbonyl chloride, 4-Biphenyl-carbonyl chloride, SCHEMBL14416, (4-phenyl)phenylcarbonyl chloride, 4-biphenylcarboxylic acid chloride, 4-phenyl-1benzenecarbonyl chloride, [1,1′-biphenyl]4carbonyl chloride, 4-phenyl-1-benzenecarbonyl chloride, biphenyl-4-carboxylic acid chloride, 1,1′-Biphenyl-4-carbonyl chloride, Biphenyl-4-carbonyl chloride, 97%, [1,1′-biphenyl]4-carbonyl chloride, [1,1-biphenyl]-4-carbonyl chloride, 4-[1,1′-biphenyl]carbonyl chloride, [1,1′-biphenyl]-4 carbonyl chloride, [1,1′-biphenyl]4-carbo-nyl chloride, 4-(1,1′-biphenyl) carbonyl chloride, AKOS005256900, FP00419, [1,1′-biphenyl]-4-carbo-nyl chloride, SY048529, DB-042501, NS00051251, P1079, ST51037514, Q27265350, 4-Biphenylcarbonyl chloride;Biphenyl-4-carbonylchloride

Application

4-Phenylbenzoyl chloride is primarily employed as a key intermediate in the synthesis of biphenyl-based pharmaceuticals, agrochemicals, and specialty polymers. It serves as an efficient acylating agent for introducing the 4-phenylbenzoyl moiety into target molecules, enabling the production of high-value compounds such as liquid crystal precursors and photoactive materials. Researchers also utilize this reagent in peptide coupling reactions and the development of advanced organic electronic materials.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (80.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• Eye Dam. 1 (80.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.