Description

4-(Methylsulfonyl)phenol (CAS No. 14763-60-1) is a high-purity sulfone derivative with the molecular formula C₇H₈O₃S. This compound, also known by its IUPAC name 4-methylsulfonylphenol, is a white to off-white crystalline powder widely utilized in pharmaceutical, agrochemical, and material science research. Its unique sulfonyl and phenolic functional groups make it a versatile intermediate for synthesizing bioactive molecules, polymers, and specialty chemicals. With a molecular weight of 172.20 g/mol, it offers excellent solubility in polar organic solvents such as DMSO, methanol, and acetone, ensuring ease of handling in laboratory settings. Our product is rigorously tested for purity (typically ≥98% by HPLC) and consistency, meeting the stringent demands of researchers and industrial applications.

Properties

• CAS Number: 14763-60-1
• Complexity: 206
• IUPAC Name: 4-methylsulfonylphenol
• InChI: InChI=1S/C7H8O3S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5,8H,1H3
• InChI Key: KECCFSZFXLAGJS-UHFFFAOYSA-N
• Exact Mass: 172.01941529
• Molecular Formula: C7H8O3S
• Molecular Weight: 172.20
• SMILES: CS(=O)(=O)C1=CC=C(C=C1)O
• Topological: 62.8
• Monoisotopic Mass: 172.01941529
• Synonyms: 4-(Methylsulfonyl)phenol, 4-Hydroxyphenyl methyl sulfone, Phenol, p-(methylsulfonyl)-, p-(Methylsulfonyl)phenol, p-Hydroxyphenyl methyl sulfone, UNII-F7BIF7ZQJ9, 4-(methanesulfonyl)phenol, F7BIF7ZQJ9, P-(METHANESULFONYL)PHENOL, DTXSID80163763, BENZENE,1-HYDROXY,4-METHYLSULFONYL (PHENOL,4-METHYLSULFONYL), DTXCID6086254, 632-596-9, inchi=1/c7h8o3s/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5,8h,1h, 14763-60-1, 4-methylsulfonylphenol, phenol, 4-(methylsulfonyl)-, 4-methanesulfonylphenol, 4-Methanesulfonyl-phenol, 4-methylsulphonylphenol, MFCD00047806, CHEMBL66861, 4-methylsulfonyl phenol, 4-(methylsulphonyl)phenol, phenol, 4-mesyl-, p-methylsulphonylphenol, 4-methylsulfonyl-phenol, p-methyl sulfonyl phenol, 4-(methylsulfonyl) phenol, 4-(Methylsulfonyl)-phenol, SCHEMBL1535, SCHEMBL517832, SCHEMBL3591711, KECCFSZFXLAGJS-UHFFFAOYSA-N, BDBM50266956, SBB049566, STK505595, AKOS005171779, AB02067, AC-1241, CS-W004825, FM36053, PS-3171, BP-10814, SY007820, DB-008353, H1367, ST50405748, 4-(Methylsulfonyl)phenol, analytical standard, EN300-23056, O11094, AE-848/33833060, Q27277760, 4-Hydroxyphenyl methyl sulfone;4-Methanesulphonylphenol, Z147646800

Application

4-(Methylsulfonyl)phenol serves as a key intermediate in the synthesis of sulfonamide-based pharmaceuticals, including COX-2 inhibitors and antimicrobial agents. It is also employed in agrochemical research for developing novel herbicides and fungicides due to its bioactive sulfonyl moiety. Additionally, this compound finds use in polymer chemistry as a crosslinking agent or monomer for high-performance materials.

Safety and Hazards

GHS Hazard Statements

• H315 (14.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (14.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (14.9%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (14.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.