Atomfair 4-Methylenepiperidine hydrochloride C6H12ClN CAS 144230-50-2

Description

4-Methylenepiperidine hydrochloride (CAS No. 144230-50-2) is a high-purity organic compound with the molecular formula C₆H₁₂ClN. This hydrochloride salt of 4-methylidenepiperidine is a versatile intermediate in pharmaceutical and chemical synthesis, offering excellent reactivity for nucleophilic addition and alkylation reactions. Its rigid piperidine scaffold with a methylene group at the 4-position makes it a valuable building block for drug discovery, particularly in the development of CNS-active compounds and bioactive alkaloids. Our product is rigorously tested to ensure ≥95% purity (HPLC) and is supplied as a white to off-white crystalline powder, packaged under inert conditions to guarantee stability. Ideal for medicinal chemistry, this compound is available in research quantities (100mg to 10g) with optional analytical certificates (CoA, MSDS).

Properties

• CAS Number: 144230-50-2
• Complexity: 68.2
• IUPAC Name: 4-methylenepiperidine;hydrochloride
• InChI: InChI=1S/C6H11N.ClH/c1-6-2-4-7-5-3-6;/h7H,1-5H2;1H
• InChI Key: XGMSENVPQPNOHF-UHFFFAOYSA-N
• Exact Mass: 133.0658271
• Molecular Formula: C6H12ClN
• Molecular Weight: 133.62
• SMILES: C=C1CCNCC1.Cl
• Topological: 12
• Monoisotopic Mass: 133.0658271
• Synonyms: 4-methylenepiperidine hydrochloride, 820-104-7, 144230-50-2, 4-Methylenepiperidine HCl, 4-methylidenepiperidine hydrochloride, Piperidine, 4-methylene-, hydrochloride (1:1), 4-methylidenepiperidine;hydrochloride, MFCD17977038, 4-Methylenepiperidinehydrochloride, 4-methylidenepiperidine,hydrochloride, 4-METHYLENE PIPERIDINE HYDROCHLORIDE, SCHEMBL1338990, DTXSID20627435, XGMSENVPQPNOHF-UHFFFAOYSA-N, 4-methylene-piperidine hydrochloride, BCP15107, CS-D0508, AKOS015844463, FM64058, SB14627, AS-43132, SY022740, DB-113397, EN300-70265, 4-Methylidenepiperidine–hydrogen chloride (1/1), F8888-3171, Z1124146875

Application

4-Methylenepiperidine hydrochloride serves as a key synthon in the preparation of pharmacologically active piperidine derivatives, particularly in opioid receptor modulators and neurokinin antagonists. Its reactive methylene group facilitates Michael additions and cyclization reactions for heterocyclic compound libraries. Researchers utilize this compound in structure-activity relationship (SAR) studies targeting neurological disorders and pain management pathways.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (25%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (25%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Skin Corr. 1B (25%)
• Skin Irrit. 2 (75%)
• Eye Dam. 1 (25%)
• Eye Irrit. 2A (75%)
• STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.