Description

4-Hydrazinylbenzenesulfonamide hydrochloride (CAS No. 17852-52-7) is a high-purity sulfonamide derivative with the molecular formula C₆H₁₀ClN₃O₂S. This compound is widely utilized in organic synthesis, pharmaceutical research, and biochemical applications due to its reactive hydrazinyl functional group. The hydrochloride salt form enhances stability and solubility, making it ideal for experimental workflows. With a molecular weight of 223.68 g/mol, it is supplied as a white to off-white crystalline powder, ensuring consistent performance in sensitive reactions. Suitable for researchers requiring precise sulfonamide modifications or hydrazine-based intermediates.

Properties

• CAS Number: 17852-52-7
• Complexity: 226
• IUPAC Name: 4-hydrazinobenzenesulfonamide;hydrochloride
• InChI: InChI=1S/C6H9N3O2S.ClH/c7-9-5-1-3-6(4-2-5)12(8,10)11;/h1-4,9H,7H2,(H2,8,10,11);1H
• InChI Key: IKEURONJLPUALY-UHFFFAOYSA-N
• Exact Mass: 223.0182254
• Molecular Formula: C6H10ClN3O2S
• Molecular Weight: 223.68
• SMILES: C1=CC(=CC=C1NN)S(=O)(=O)N.Cl
• Topological: 107
• Monoisotopic Mass: 223.0182254
• Synonyms: 4-hydrazinylbenzenesulfonamide Hydrochloride, 479-480-2, 17852-52-7, 27918-19-0, 4-hydrazinobenzene-1-sulfonamide hydrochloride, 4-Hydrazinobenzenesulfonamide Hydrochloride, 4-Sulfonamidophenylhydrazine hydrochloride, 4-sulfonamide-phenylhydrazine hydrochloride, (4-sulfamoylphenyl)hydrazine hydrochloride, Benzenesulfonamide, 4-hydrazinyl-, hydrochloride (1:1), MFCD00052262, 4-Hydrazinylbenzenesulfonamide hydrochloride(1:x), Benzenesulfonamide, 4-hydrazino-, monohydrochloride, Phenylhydrazine-4-sulfonamide hydrochloride, 4-hydrazinylbenzenesulfonamide;hydrochloride, 4-Sulfonamidophenylhydrazine, HCl, 4-Hydrazinylbenzenesulfonamide xhydrochloride, (4-Sulfamoylphenyl)hydrazine-d4Hydrochloride, 4-hydrazinylbenzene-1-sulfonamide hydrochloride, 4-sulfonamidephenylhydrazine hcl, [4-(Aminosulfonyl)phenyl]hydrazine Hydrochloride, 4-Hydrazino-benzenesulfonamide hydrochloride, Benzenesulfonamide, 4-hydrazino-, hydrochloride, 4-sulfamoylphenyl hydrazine hydrochloride, p-Sulfonamidophenyl hydrazine hydrochloride, SCHEMBL981171, DTXSID70939095, 9D634JG95C, BCP26877, 4-(Sulfamoyl phenyl) hydrazine HCl, 4-sulfamylphenylhydrazine hydrochloride, AKOS005063371, 4-hydrazinylbenzenesulfonamide HCl salt, 4-sulfamoylphenylhydrazine hydrochloride, CS-W019536, FS38135, FS45225, SB80556, 4-sulfamyl-phenylhydrazine hydrochloride, 4-sulfamylphenyl hydrazine hydrochloride, 4-sulfamylphenyl-hydrazine hydrochloride, 4sulfonamidophenylhydrazine hydrochloride, 4-sulfonamidephenylhydrazine hydrochloride, 4sulfonamido phenylhydrazine hydrochloride, AC-26822, AS-10778, p-Hydrazinobenzenesulfonamide hydrochloride, SY036804, 4-Hydrazinylbenzenesulfonamidexhydrochloride, 4-sulfonamido phenylhydrazine hydrochloride, 4-(Sulfamoylphenyl) hydrazine hydrochloride, 4-hydrazino benzenesulfonamide hydrochloride, DB-001267, DB-047302, 4-hydrazine benzene sulfonamide hydrochloride, H1230, ST50825744, (p-Sulfamoylphenyl)hydrazine monohydrochloride, 4-Sulfonamido-phenyl -Hydrazine Hydrochloride, EN300-08026, 4-(Aminosulfonyl)-phenylhydrazine hydrochloride, Benzenesulfonamide, p-hydrazino-, monohydrochloride, A1-00279, 4-sulfonamidophenylhydrazine hydrochloride, AldrichCPR, Z56844958, F8881-0160, 4-Hydrazinylbenzene-1-sulfonamide–hydrogen chloride (1/1)

Application

4-Hydrazinylbenzenesulfonamide hydrochloride serves as a key intermediate in the synthesis of sulfonamide-based pharmaceuticals, including antimicrobial and diuretic agents. Its hydrazinyl group enables conjugation with carbonyl compounds, facilitating the development of hydrazone derivatives for drug discovery. Researchers also employ it in the preparation of dyes and analytical reagents. The compound’s reactivity makes it valuable in heterocyclic chemistry and as a building block for specialized polymers.

Safety and Hazards

GHS Hazard Statements

• H302 (85.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (14.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (85.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H318 (28.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (71.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H400 (85.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410 (85.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P391, and P501

Hazard Classes and Categories

• Acute Tox. 4 (85.7%)
• Skin Irrit. 2 (14.3%)
• Skin Sens. 1A (85.7%)
• Eye Dam. 1 (28.6%)
• Eye Irrit. 2 (71.4%)
• Aquatic Acute 1 (85.7%)
• Aquatic Chronic 1 (85.7%)

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