Description

4-Fluorothiophenol (CAS 371-42-6) is a high-purity organosulfur compound with the molecular formula C₆H₅FS, widely utilized in pharmaceutical, agrochemical, and materials science research. This aromatic thiol derivative, also known as 4-fluorobenzenethiol, features a fluorine substituent at the para position, enhancing its reactivity in nucleophilic and coupling reactions. Its low molecular weight (128.17 g/mol) and liquid state at room temperature make it ideal for precise synthetic applications. Available in sealed ampules or bottles under inert gas to prevent oxidation, our ≥98% purity grade ensures consistent performance in Suzuki-Miyaura cross-couplings, thiol-ene click chemistry, and ligand synthesis. Compatible with anhydrous conditions and sensitive to light, proper storage at 2-8°C is recommended.

Properties

• CAS Number: 371-42-6
• Complexity: 66.9
• IUPAC Name: 4-fluorobenzenethiol
• InChI: InChI=1S/C6H5FS/c7-5-1-3-6(8)4-2-5/h1-4,8H
• InChI Key: OKIHXNKYYGUVTE-UHFFFAOYSA-N
• Exact Mass: 128.00959950
• Molecular Formula: C6H5FS
• Molecular Weight: 128.17
• SMILES: C1=CC(=CC=C1F)S
• Topological: 1
• Monoisotopic Mass: 128.00959950
• Synonyms: 4-Fluorothiophenol, EINECS 206-737-6, DTXSID20190593, NSC 77081, DTXCID60113084, 206-737-6, 371-42-6, 4-Fluorobenzenethiol, p-Fluorothiophenol, Benzenethiol, 4-fluoro-, 4-fluorobenzene-1-thiol, 4-Fluoro thiophenol, 4-Fluoro-benzenethiol, 4-Mercaptofluorobenzene, MFCD00004846, NSC-77081, p-Fluorophenyl mercaptan, 4-fluorthiophenol, 4-luorobenzenethiol, p-fluoro-thiophenol, NSC77081, 4-fluoro-thiophenol, 4-fluoro benzenethiol, 4-fluorobenzene thiol, 4-Fluoro-phenyl thiol, 4-Fluorobenzenethiol #, HG92UTY2JE, 4-Fluorothiophenol, 98%, SCHEMBL18720, SCHEMBL544397, CHEMBL333626, CHEBI:189138, CK1157, AKOS000120799, FF34648, PS-11969, DB-049075, CS-0015928, F0393, NS00041464, EN300-20848, F0001-1066

Application

4-Fluorothiophenol serves as a key intermediate in the synthesis of fluorinated pharmaceuticals and liquid crystal materials. Its thiol group enables functionalization of gold nanoparticles and surfaces for biosensor development. Researchers also employ it as a building block for heterocyclic compounds in medicinal chemistry programs targeting kinase inhibitors.

Safety and Hazards

GHS Hazard Statements

• H226 (98.9%): Flammable liquid and vapor [Warning Flammable liquids]
• H300 (48.9%): Fatal if swallowed [Danger Acute toxicity, oral]
• H310 (48.9%): Fatal in contact with skin [Danger Acute toxicity, dermal]
• H315 (97.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (48.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (96.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H330 (43.2%): Fatal if inhaled [Danger Acute toxicity, inhalation]
• H335 (53.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H400 (48.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410 (48.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P319, P320, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (98.9%)
• Acute Tox. 2 (48.9%)
• Acute Tox. 2 (48.9%)
• Skin Irrit. 2 (97.7%)
• Skin Sens. 1 (48.9%)
• Eye Irrit. 2 (96.6%)
• Acute Tox. 2 (43.2%)
• STOT SE 3 (53.4%)
• Aquatic Acute 1 (48.9%)
• Aquatic Chronic 1 (48.9%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.