Description

4-Fluorosalicylic Acid (CAS No. 345-29-9) is a fluorinated derivative of salicylic acid with the molecular formula C₇H₅FO₃. This high-purity compound, also known as 4-fluoro-2-hydroxybenzoic acid, is a valuable building block in organic synthesis and pharmaceutical research. Its unique structure, featuring both a carboxylic acid and a hydroxyl group on a fluorinated benzene ring, makes it a versatile intermediate for developing bioactive molecules, agrochemicals, and advanced materials.

Our 4-Fluorosalicylic Acid is rigorously tested to ensure ≥98% purity (HPLC), with stringent quality control for consistent performance. It is supplied as a white to off-white crystalline powder, soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). Suitable for laboratory and industrial use, this compound is packaged under inert conditions to guarantee stability and longevity.

Key Synonyms: EINECS 206-459-5, DTXSID80188057, NSC 109099, DTXCID10110548.

Properties

• CAS Number: 345-29-9
• Complexity: 160
• IUPAC Name: 4-fluoro-2-hydroxy-benzoic acid
• InChI: InChI=1S/C7H5FO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,(H,10,11)
• InChI Key: TTZOLDXHOCCNMF-UHFFFAOYSA-N
• Exact Mass: 156.02227218
• Molecular Formula: C7H5FO3
• Molecular Weight: 156.11
• SMILES: C1=CC(=C(C=C1F)O)C(=O)O
• Topological: 57.5
• Monoisotopic Mass: 156.02227218
• Synonyms: 4-Fluorosalicylic acid, EINECS 206-459-5, DTXSID80188057, NSC 109099, DTXCID10110548, 206-459-5, 4-Fluoro-2-hydroxybenzoic Acid, 345-29-9, MFCD00153168, 4-fluorosalicyclic acid, 2-hydroxy-4-fluorobenzoic acid, 4-fluoro-2-hydroxy-benzoic acid, Benzoic acid, 4-fluoro-2-hydroxy-, 4-FLUORO-2-HYDROXYBENZOICACID, SCHEMBL188203, 4-Fluorosalicylic acid, 96%, CHEMBL1650626, 2-hydroxy-4-fluoro-benzoic acid, 4-fluoro-2-hydroxy benzoic acid, BBL100834, CL8118, NSC109099, SBB052701, STL554628, AKOS005255687, AC-3961, CS-W008186, FF64203, FS-1263, HY-W008186, NSC-109099, SY012802, F0637, NS00041888, ST50824551, EN300-56429, Z854336256, OOI

Application

4-Fluorosalicylic Acid is widely used as a precursor in the synthesis of fluorinated pharmaceuticals, including nonsteroidal anti-inflammatory drugs (NSAIDs) and antimicrobial agents. Its fluorine moiety enhances metabolic stability and bioavailability in drug design. Researchers also employ it in material science to develop liquid crystals and specialty polymers. Additionally, it serves as a derivatization agent in analytical chemistry for detecting phenolic compounds.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.