Description

4-Fluorophenol (CAS No. 371-41-5) is a high-purity fluorinated aromatic compound with the molecular formula C₆H₅FO. This versatile intermediate is widely used in pharmaceutical, agrochemical, and material science research due to its reactive phenolic hydroxyl group and para-fluorine substitution. Available in crystalline form with ≥98% purity (GC), it exhibits excellent solubility in organic solvents like ethanol, methanol, and dimethyl sulfoxide (DMSO).

Our 4-Fluorophenol is rigorously tested for impurities (HPLC, NMR) and packaged under inert gas to ensure stability. Ideal for nucleophilic substitution reactions, Suzuki couplings, and as a building block for advanced fluorinated compounds. SDS and analytical certificates are available upon request.

Properties

• CAS Number: 371-41-5
• Complexity: 66.9
• IUPAC Name: 4-fluorophenol
• InChI: InChI=1S/C6H5FO/c7-5-1-3-6(8)4-2-5/h1-4,8H
• InChI Key: RHMPLDJJXGPMEX-UHFFFAOYSA-N
• Exact Mass: 112.032442941
• Molecular Formula: C6H5FO
• Molecular Weight: 112.10
• SMILES: C1=CC(=CC=C1O)F
• Topological: 20.2
• Monoisotopic Mass: 112.032442941
• Physical Description: White crystalline solid with an odor like phenol;
• Vapor Pressure: 1.19 [mmHg]
• Synonyms: 4-FLUOROPHENOL, p-Fluorophenol, Phenol, 4-fluoro-, Phenol, p-fluoro-, CCRIS 665, EINECS 206-736-0, K6DT6TR5E5, NSC 10295, BRN 1362752, NSC-10295, FLUOROPHENOL, 4-, 4-HYDROXYPHENYL FLUORIDE, DTXSID0052047, CHEBI:42533, EC 206-736-0, 4-06-00-00773 (Beilstein Handbook Reference), Phenol, pfluoro, Phenol, 4fluoro, DTXCID5030614, 206-736-0, rhmpldjjxgpmex-uhfffaoysa-n, un2923, 371-41-5, MFCD00002316, 4-Fluoro-phenol, PARA-FLUOROPHENOL, FPN, 4fluorophenol, p-fluoro phenol, p-fluoro-phenol, 4-flourophenol, 4fluoro phenol, 4-flurophenol, 4-fluoro phenol, 4-fluoranylphenol, 4-Fluorophenol, 99%, UNII-K6DT6TR5E5, SCHEMBL78213, SCHEMBL239776, SCHEMBL303555, SCHEMBL1467493, DTXSID00175727, NSC10295, SBB040810, STL183322, AKOS000119023, CCG-302492, CS-W008731, FF31943, PS-9253, DB-028894, F0160, NS00009958, ST50214377, EN300-19431, A823540, Q27460393, F0001-1065

Application

4-Fluorophenol serves as a key synthon in pharmaceutical development, particularly for fluorinated drug candidates targeting CNS disorders. It’s employed as a precursor for liquid crystal materials and agrochemicals due to its electron-withdrawing properties. Researchers also utilize it in PET radiotracer synthesis and as a modifier in polymer chemistry.

Safety and Hazards

GHS Hazard Statements

• H302 (98.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (94.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (56.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (43.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (49.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (44.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (89.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (92%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H412 (53.6%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (98.2%)
• Acute Tox. 4 (94.6%)
• Skin Corr. 1B (56.2%)
• Skin Irrit. 2 (43.8%)
• Eye Dam. 1 (49.1%)
• Eye Irrit. 2 (44.6%)
• Acute Tox. 4 (89.3%)
• STOT SE 3 (92%)
• Aquatic Chronic 3 (53.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.