Description

(4-Fluorooxan-4-yl)methanol (CAS No. 883442-46-4) is a high-purity fluorinated heterocyclic compound with the molecular formula C₆H₁₁FO₂. This specialty chemical features a tetrahydropyran (oxane) ring substituted with a fluorine atom and a hydroxymethyl group at the 4-position, offering unique reactivity for advanced synthetic applications. With a molar mass of 134.15 g/mol, this compound is supplied as a clear, colorless to pale yellow liquid or low-melting solid, typically with ≥95% purity (GC). Its structural motif makes it a valuable scaffold in medicinal chemistry, agrochemical research, and material science. Proper storage under inert atmosphere at 2-8°C is recommended to maintain stability. Available in research quantities from milligrams to kilograms, this product is ideal for pharmaceutical intermediates, fluorinated building blocks, and asymmetric synthesis.

Properties

• CAS Number: 883442-46-4
• Complexity: 89.1
• IUPAC Name: (4-fluorotetrahydropyran-4-yl)methanol
• InChI: InChI=1S/C6H11FO2/c7-6(5-8)1-3-9-4-2-6/h8H,1-5H2
• InChI Key: SCZDHDHAWKBYHY-UHFFFAOYSA-N
• Exact Mass: 134.07430775
• Molecular Formula: C6H11FO2
• Molecular Weight: 134.15
• SMILES: C1COCCC1(CO)F
• Topological: 29.5
• Monoisotopic Mass: 134.07430775
• Synonyms: 883442-46-4, (4-FLUOROOXAN-4-YL)METHANOL, 864-686-0, (4-FLUOROTETRAHYDRO-2H-PYRAN-4-YL)METHANOL, 4-HYDROXYMETHYL-4-FLUORO-TETRAHYDRO-2H-PYRAN, 2H-PYRAN-4-METHANOL, 4-FLUOROTETRAHYDRO-, MFCD18072006, (4-FLUORO-TETRAHYDRO-PYRAN-4-YL)-METHANOL, SCHEMBL522752, SCZDHDHAWKBYHY-UHFFFAOYSA-N, 4-Fluorotetrahydropyran-4-methanol, IKB44246, AKOS022178062, (4-fluorotetrahydropyran-4-yl)methanol, PB21247, (4-Fluorotetrahydropyran-4-yl)-methanol, 4-(Hydroxymethyl)-4-fluorotetrahydropyran, 4-fluorotetrahydro-2H-pyran-4-ylmethanol, AS-34527, DA-40892, SY097191, CS-0053200, (4-fluorotetrahydro-2H-pyran-4-yl) methanol, EN300-1215432, F2167-8034

Application

This fluorinated oxane derivative serves as a versatile building block in organic synthesis, particularly for introducing both fluorine and alcohol functionalities in target molecules. Researchers utilize it in the development of novel pharmaceutical candidates, especially for CNS-targeting drugs due to its ability to modulate blood-brain barrier penetration. The compound’s rigid cyclic structure also makes it valuable for constructing conformationally constrained analogs in structure-activity relationship studies.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.