Description

4-Fluorobenzoyl chloride (CAS No. 403-43-0) is a highly reactive organic compound with the molecular formula C₇H₄ClFO. This aromatic acyl chloride is a clear to pale yellow liquid with a pungent odor, commonly used as a key intermediate in organic synthesis and pharmaceutical manufacturing. Its structure features a fluorine substituent at the para position of the benzoyl chloride group, enhancing its reactivity in nucleophilic substitution and acylation reactions. Suitable for laboratory and industrial applications, this compound is stored under inert conditions to prevent hydrolysis. Available in high purity grades (≥98%), it is ideal for researchers requiring precise and reliable reagents for complex chemical transformations.

Properties

• CAS Number: 403-43-0
• Complexity: 130
• IUPAC Name: 4-fluorobenzoyl chloride
• InChI: InChI=1S/C7H4ClFO/c8-7(10)5-1-3-6(9)4-2-5/h1-4H
• InChI Key: CZKLEJHVLCMVQR-UHFFFAOYSA-N
• Exact Mass: 157.9934706
• Molecular Formula: C7H4ClFO
• Molecular Weight: 158.56
• SMILES: C1=CC(=CC=C1C(=O)Cl)F
• Topological: 17.1
• Monoisotopic Mass: 157.9934706
• Physical Description: Colorless liquid with a pungent odor; mp = 10-12 deg C;
• Synonyms: 4-Fluorobenzoyl chloride, 403-43-0, Benzoyl chloride, 4-fluoro-, p-Fluorobenzoyl chloride, Benzoyl chloride, p-fluoro-, p-Fluorobenzoic acid chloride, EINECS 206-961-4, NSC 88305, DTXSID5059953, CZKLEJHVLCMVQR-UHFFFAOYSA-, pFluorobenzoyl chloride, Benzoyl chloride, pfluoro, Benzoyl chloride, 4fluoro, pFluorobenzoic acid chloride, DTXCID2039750, 206-961-4, inchi=1/c7h4clfo/c8-7(10)5-1-3-6(9)4-2-5/h1-4h, 4-fluorobenzoylchloride, MFCD00000684, 4-Fluorobenzoic acid chloride, 4-fluoro-benzoyl chloride, 4-Fluoro benzoyl chloride, WW9JD3YJ9Q, NSC-88305, p-fluorobenzoylchloride, p-fluorobenzoyl choride, 4-flurobenzoyl chloride, 4-fluoro benzoylchloride, 4-fluoro-benzoylchloride, 4-fluorobenzoic chloride, 4-fluorobenzoyl-chloride, para-fluorobenzoylchloride, UNII-WW9JD3YJ9Q, 4-Fluoro-benzoyl-chloride, para-Fluorobenzoyl chloride, 4-fluoranylbenzoyl chloride, SCHEMBL1649, 4-fluorophenylcarbonyl chloride, 4-Fluorobenzenecarbonyl chloride, 4-Fluorobenzoyl chloride, 98%, 4-fluorobenzene carbonyl chloride, 4-fluoro-1-benzenecarbonyl chloride, NSC88305, CK1093, SBB040628, AKOS000268647, FF64280, PB42763, 4-fluoro-phenyl carboxylic acid chloride, AS-45825, DB-013254, F0213, NS00043203, ST50214061, EN300-19251, A825063, F2190-0060

Application

4-Fluorobenzoyl chloride is widely employed as a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It serves as a critical intermediate in the preparation of fluorinated benzophenones, amides, and esters through acylation reactions. Researchers utilize it in peptide coupling and polymer chemistry due to its high reactivity with nucleophiles. Its fluorine moiety enhances the metabolic stability of derived compounds, making it valuable in drug discovery.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.