Description

4-Fluorobenzoic Acid (CAS No. 456-22-4) is a high-purity fluorinated aromatic carboxylic acid with the molecular formula C₇H₅FO₂. This white to off-white crystalline powder is a versatile building block in organic synthesis and pharmaceutical research. With a molecular weight of 140.11 g/mol, it offers excellent solubility in organic solvents like ethanol, methanol, and dimethyl sulfoxide (DMSO), while being sparingly soluble in water. The compound features a fluorine substituent at the para position of the benzoic acid ring, making it valuable for studying electronic effects in aromatic systems. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied in secure, chemically resistant packaging. Ideal for use in Suzuki couplings, peptide synthesis, and as a precursor for liquid crystals or pharmaceutical intermediates.

Properties

• CAS Number: 456-22-4
• Complexity: 128
• IUPAC Name: 4-fluorobenzoic acid
• InChI: InChI=1S/C7H5FO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)
• InChI Key: BBYDXOIZLAWGSL-UHFFFAOYSA-N
• Exact Mass: 140.02735756
• Molecular Formula: C7H5FO2
• Molecular Weight: 140.11
• SMILES: C1=CC(=CC=C1C(=O)O)F
• Topological: 37.3
• Monoisotopic Mass: 140.02735756
• Physical Description: Solid; Light yellow powder;
• Vapor Pressure: 0.01 [mmHg]
• Synonyms: 4-FLUOROBENZOIC ACID, 456-22-4, p-Fluorobenzoic acid, Benzoic acid, 4-fluoro-, para-Fluorobenzoic acid, Benzoic acid, p-fluoro-, V5ROO2HOU4, CHEBI:20364, EINECS 207-259-0, NSC 10321, NSC-10321, FLUOROBENZOIC ACID, P-, DTXSID9060023, 4-FLUOROBENZOIC ACID [MI], 4fluorobenzoic acid, Benzoic acid, pfluoro, Benzoic acid, 4fluoro, Benzoic acid, pfluoro (8CI), Benzoic acid, p-fluoro-(8CI), DTXCID3040435, 207-259-0, 695-034-1, 4-fluorobenzoic acid, anhydride, inchi=1/c7h5fo2/c8-6-3-1-5(2-4-6)7(9)10/h1-4h,(h,9,10, 4-fluoro-benzoic acid, 4-fluoro benzoic acid, MFCD00002530, p-flurobenzoic acid, 4-flurobenzoic acid, NSC 10321; p-Fluorobenzoic Acid;, 4-Fluorobenzoicacid, p-fluoro-Benzoic acid, UNII-V5ROO2HOU4, 1Y6, 4-flouro benzoic acid, bmse000739, SCHEMBL27498, 4-Fluorobenzoic acid, 98%, SCHEMBL185207, CHEMBL316860, SCHEMBL2163765, SCHEMBL3340202, NSC10321, SBB008568, STL141031, AKOS000118941, CS-W014393, HY-W013677, PS-9056, AC-10259, SY001592, DB-024083, 4-Fluorobenzoic acid,purified by sublimation, F0112, NS00080419, ST50823659, EN300-18213, C02371, D70922, AE-562/40177766, 4-Fluorobenzoic acid, 99%, purified by sublimation, Q63390495, Z57367354, F2191-0062

Application

4-Fluorobenzoic Acid serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, agrochemicals, and specialty materials. Researchers utilize it to study structure-activity relationships in drug design due to its electron-withdrawing fluorine moiety. The compound finds application in polymer chemistry as a monomer for fluorinated polyesters and as a building block for liquid crystal displays (LCDs). In analytical chemistry, it’s employed as a standard for fluorine-containing compound analysis.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P270, P280, P301+P317, P305+P354+P338, P317, P330, and P501

Hazard Classes and Categories

• Acute Tox. 4 (77.4%)
• Skin Irrit. 2 (17%)
• Eye Dam. 1 (77.4%)
• Eye Irrit. 2 (17%)
• STOT SE 3 (13.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.