Description

4-Fluoroaniline (CAS No. 371-40-4) is a high-purity aromatic amine compound widely used in pharmaceutical, agrochemical, and material science research. This organic intermediate features a fluorine substituent at the para position of aniline, enhancing its reactivity in electrophilic substitution and coupling reactions. With the molecular formula C₆H₆FN, it is a clear to pale-yellow liquid (or solid below 1°C) with a density of 1.172 g/mL at 25°C. Our product is rigorously tested to ensure ≥97% purity (GC), ideal for synthesizing fluorinated dyes, liquid crystals, and active pharmaceutical ingredients (APIs). Packaged under inert gas to prevent oxidation, it is supplied in amber glass bottles or bulk quantities with customizable COA/MSDS documentation. Hazard Class 6.1 (UN2941)—handle with appropriate PPE.

Properties

• CAS Number: 371-40-4
• Complexity: 66.9
• IUPAC Name: 4-fluoroaniline
• InChI: InChI=1S/C6H6FN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2
• InChI Key: KRZCOLNOCZKSDF-UHFFFAOYSA-N
• LogP: log Kow = 1.15
• Exact Mass: 111.048427358
• Molecular Formula: C6H6FN
• Molecular Weight: 111.12
• SMILES: C1=CC(=CC=C1N)F
• Topological: 26
• Monoisotopic Mass: 111.048427358
• Physical Description: 4-fluoroaniline is a light-colored oily liquid. Mixture of three isomers. Insoluble in water and denser than water. Contact may cause irritation to skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals.
• Color/Form: Liquid
• Boiling Point: 358.7 °F at 760 mmHg
• Melting Point: 30.6 °F
• Flash Point: 165 °F
• Solubility: In water, 33 g/L at 20 °C
• Density: 1.1725 at 68 °F – Denser than water; will sink
• Vapor Pressure: 1.0 [mmHg]
• Heat of Combustion: 780.4 kcal/mol
• Refractive Index: Index of refraction: 1.51954 at 20 °C/D
• Dissociation Constants: pKa = 4.65 at 25 °C
• Synonyms: 4-FLUOROANILINE, 371-40-4, p-Fluoroaniline, 1-Amino-4-fluorobenzene, 4-Fluorobenzenamine, Benzenamine, 4-fluoro-, p-Fluorophenylamine, Aniline, p-fluoro-, 4-Fluoronaniline, Aniline, 4-fluoro-, para-Fluoroaniline, 4-Fluoro-phenylamine, 4-Fluoranilin, 4-fluorophenylamine, 4-Fluoranilin [Czech], Fluoroaniline, p-, p-aminofluorobenzene, NSC 579, CCRIS 5059, DTXSID9022027, CHEBI:28546, 4-fluoraniline, HSDB 2691, EINECS 206-735-5, UNII-60HI1G076Z, BRN 0742030, AI3-52386, NSC-579, 60HI1G076Z, 4-FLUOROANILINE [MI], DTXCID602027, 4-FLUOROANILINE [HSDB], EC 206-735-5, 4-12-00-01104 (Beilstein Handbook Reference), UN 2944, fluoranilin, Fluoroanilines, pFluoroaniline, 4Fluoronaniline, 4Fluoranilin, paraFluoroaniline, Aniline, pfluoro, pFluorophenylamine, 4Fluorobenzenamine, Aniline, 4fluoro, 1Amino4fluorobenzene, Fluoranilin (Czech), Benzenamine, 4fluoro, Aniline, p-fluoro-(8CI), 206-735-5, 371-40-487686-42-8, inchi=1/c6h6fn/c7-5-1-3-6(8)4-2-5/h1-4h,8h, krzcolnoczksdf-uhfffaoysa-n, un2941, MFCD00007829, 4-fluorobenzenaminium, (4-fluorophenyl)-amine, CHEMBL32014, 4flouroaniline, p-fluoraniline, 4-flouroaniline, 4-fluoroanaline, 4-floroaniline, 4-fluoroanilin, 4-fluroaniline, p-fluoro-aniline, picolinafen TP2, 4 -fluoroaniline, 4- fluoroaniline, 4-fluoro aniline, 4-fluoro-aniline, 4-fluoranylaniline, 4-fluorobenzeneamine, (4-fluorophenyl)amine, 1,4-fluorobenzenamine, 4-Fluoro-1-benzenamine, 4-fluoro-1-aminobenzene, 4-Fluoroaniline, 99%, WLN: ZR DF, SCHEMBL3199, SCHEMBL197720, SCHEMBL654638, NSC579, SCHEMBL1315855, SCHEMBL2683514, BCP21217, Tox21_202828, BDBM50282614, SBB040453, STL168895, AKOS000119114, FF23415, PS-9263, NCGC00260374-01, CAS-371-40-4, PD055449, DB-023950, F0033, NS00010860, ST45255294, 4-Fluoroaniline, technical, >=97.0% (GC), EN300-18060, D78529, A823539, p-Fluoroaniline [UN2941] [Keep away from food], Q27103764, Z57127563, F2190-0427, 1-Amino-4-fluorobenzene;4-Fluorobenzenamine;4-Fluorophenylamine

4-Fluoroaniline serves as a key building block in the synthesis of fluorinated heterocycles and advanced materials. It is extensively used in Suzuki-Miyaura cross-coupling reactions to create biaryl structures for drug discovery. In agrochemistry, it acts as a precursor for herbicides and pesticides. Its electron-withdrawing fluorine group also facilitates the development of OLEDs and liquid crystal displays (LCDs).

Safety and Hazards

GHS Hazard Statements

• H227: Combustible liquid [Warning Flammable liquids]
• H302: Harmful if swallowed [Warning Acute toxicity, oral]
• H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]
• H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P264, P264+P265, P270, P273, P280, P301+P317, P305+P351+P338, P330, P337+P317, P370+P378, P403, and P501

Hazard Classes and Categories

• Acute Tox. 4 (98%)
• Skin Corr. 1C (96.6%)
• Eye Dam. 1 (74%)
• STOT RE 2 (56.9%)
• Aquatic Acute 1 (72.5%)
• Aquatic Chronic 1 (73%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.