Description

4′-Fluoroacetophenone (CAS No. 403-42-9) is a high-purity fluorinated aromatic ketone with the molecular formula C₈H₇FO. This compound, also known by its IUPAC name 1-(4-fluorophenyl)ethanone, is a versatile building block in organic synthesis and pharmaceutical research. It features a fluorine substituent at the para position of the acetophenone ring, enhancing its reactivity in electrophilic and nucleophilic reactions. Ideal for use in Suzuki couplings, Grignard reactions, and as a precursor for fluorinated intermediates, this product is rigorously tested for purity (typically ≥98% by GC) and consistency. Available in scalable quantities, it is supplied in secure, chemically resistant packaging to ensure stability and shelf life. Suitable for researchers in medicinal chemistry, material science, and fine chemical synthesis.

Properties

• CAS Number: 403-42-9
• Complexity: 125
• IUPAC Name: 1-(4-fluorophenyl)ethanone
• InChI: InChI=1S/C8H7FO/c1-6(10)7-2-4-8(9)5-3-7/h2-5H,1H3
• InChI Key: ZDPAWHACYDRYIW-UHFFFAOYSA-N
• Exact Mass: 138.048093005
• Molecular Formula: C8H7FO
• Molecular Weight: 138.14
• SMILES: CC(=O)C1=CC=C(C=C1)F
• Topological: 17.1
• Monoisotopic Mass: 138.048093005
• Physical Description: Colorless to yellow liquid;
• Vapor Pressure: 0.75 [mmHg]
• Synonyms: 4′-Fluoroacetophenone, 1-(4-Fluorophenyl)ethanone, 4-FLUOROACETOPHENONE, p-Fluoroacetophenone, 1-(4-Fluorophenyl)Ethan-1-One, Ethanone, 1-(4-fluorophenyl)-, Acetophenone, 4′-fluoro-, 1-acetyl-4-fluorobenzene, UNII-TVQ090602V, P-FLUOROHYPNONE, para-Fluoroacetophenone, TVQ090602V, EINECS 206-960-9, NSC 30635, NSC-30635, 4-FLUOROPHENYLETHANAL, 4-fluorophenyl methyl ketone, 4-ACETYLPHENYL FLUORIDE, DTXSID0059952, ZDPAWHACYDRYIW-UHFFFAOYSA-, METHYL 4-FLUOROPHENYL KETONE, BROMPERIDOL DECANOATE IMPURITY L [EP IMPURITY], HALOPERIDOL DECANOATE IMPURITY L [EP IMPURITY], BROMPERIDOL DECANOATE IMPURITY L (EP IMPURITY), HALOPERIDOL DECANOATE IMPURITY L (EP IMPURITY), pFluoroacetophenone, 4fluoroacetophenone, Acetophenone, 4’fluoro, Ethanone, 1(4fluorophenyl), Acetophenone, 4’fluoro (8CI), DTXCID3039749, Acetophenone, 4′-fluoro-(8CI), inchi=1/c8h7fo/c1-6(10)7-2-4-8(9)5-3-7/h2-5h,1h3, zdpawhacydryiw-uhfffaoysa-n, 403-42-9, MFCD00000354, 1-(4-fluoro-phenyl)-ethanone, CHEMBL257923, acetophenone, p-fluoro-, 4 fluoroacetophenone, p-fluoro acetophenone, 1-(4-fluorophenyl) ethanone, 4-fluoracetophenone, 1-(4-Fluorophenyl)ethanone; Haloperidol Decanoate Imp. L (EP); Haloperidol Decanoate Impurity L, NSC30635, 4′-fluoracetophenone, 4′-fluoroactophenone, 4- fluoroacetophenone, 4-fluoro acetophenone, 4-fluoroaceto phenone, 4′ -fluoroacetophenone, 4′-fluoro-acetophenone, Pipamperone metabolite M-X, 1-fluoro-4-acetyl-benzene, SCHEMBL54677, 1-(4′-fluorophenyl)ethanone, 1-(4-fluorophenyl)-ethanone, 4′-Fluoroacetophenone, 99%, 1-(4-Fluorophenyl)ethanone #, SCHEMBL1206454, SCHEMBL1259812, SCHEMBL1601408, SCHEMBL13341603, HY-Y0779, BDBM50376210, SBB040257, STK328125, AKOS000119732, AC-3641, CS-W020117, FF37945, PS-9091, F0261, NS00043755, ST50213420, EN300-18001, D70558, 4 inverted exclamation mark(R)-Fluoroacetophenone, 1-(4-Fluorophenyl)ethanone; 4′-Fluoroacetophenone, Q27290448, Z57127466, F0001-1142

Application

4′-Fluoroacetophenone is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals, agrochemicals, and liquid crystal materials. Its para-fluorine substitution makes it valuable for designing bioactive molecules with enhanced metabolic stability and binding affinity. Researchers employ it in cross-coupling reactions to construct complex aryl-fluorine scaffolds. Additionally, it serves as a precursor for photoinitiators and specialty polymers requiring fluorinated aromatic components.

Safety and Hazards

GHS Hazard Statements

• H315 (98.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (98.5%)
• Eye Irrit. 2 (98.5%)
• STOT SE 3 (95.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.