Description

4-Fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide (CAS No. 1027345-08-9) is a highly specialized sulfonamide derivative designed for advanced research and industrial applications. This compound, with the molecular formula C₇H₅F₄NO₄S₂, features a unique trifluoromethylsulfonyl group adjacent to a fluoro-substituted benzene ring, making it a valuable intermediate in organic synthesis and pharmaceutical development. Its high purity (>98%) ensures reliable performance in catalysis, material science, and medicinal chemistry. Packaged under inert conditions to maintain stability, this product is ideal for researchers seeking precision in fluorinated sulfonamide chemistry. Available in quantities from milligrams to kilograms, it comes with comprehensive analytical data (GC/MS, NMR, HPLC) for quality assurance.

Properties

• CAS Number: 1027345-08-9
• Complexity: 501
• IUPAC Name: 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide
• InChI: InChI=1S/C7H5F4NO4S2/c8-5-2-1-4(18(12,15)16)3-6(5)17(13,14)7(9,10)11/h1-3H,(H2,12,15,16)
• InChI Key: JOESWBMGEGYULU-UHFFFAOYSA-N
• Exact Mass: 306.95961264
• Molecular Formula: C7H5F4NO4S2
• Molecular Weight: 307.2
• SMILES: C1=CC(=C(C=C1S(=O)(=O)N)S(=O)(=O)C(F)(F)F)F
• Topological: 111
• Monoisotopic Mass: 306.95961264
• Synonyms: 1027345-08-9, 4-Fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide, 4-FLUORO-3-[(TRIFLUOROMETHYL)SULFONYL]BENZENESULFONAMIDE, 821-241-5, 4-FLUORO-3-(TRIFLUOROMETHYLSULFONYL)BENZENESULFONAMIDE, Benzenesulfonamide, 4-fluoro-3-[(trifluoromethyl)sulfonyl]-, 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide, C7H5F4NO4S2, 4-fluoro-3-trifluoromethanesulfonylbenzene-1-sulfonamide, 5-Amino-1,3-diphenyl-pyrazole; 1,3-Diphenyl-1H-pyrazol-5-amine; 1,3-Diphenyl-5-aminopyrazole; 5-Amino-1,3-diphenylpyrazole, MFCD16251392, SCHEMBL554223, DTXSID10648573, BCP34569, AKOS015888186, CS-W008963, DS-14988, DB-058849, EN300-264075, 4-fluoro-3-(trifluoromethylsulfonyl)-benzenesulfonamide, 4-Fluoro-3- ((trifluoromethyl)sulfonyl)benzenesulfonamide, 4-Fluoro-3-((trifluoromethyl)-sulfonyl)benzenesulfonamide, 4-Fluoro-3-(trifluoromethanesulfonyl)benzene-1-sulfonamide

This compound is primarily used as a key intermediate in the synthesis of fluorinated sulfonamide-based pharmaceuticals and agrochemicals. Its reactive sulfonamide and trifluoromethylsulfonyl groups enable participation in cross-coupling reactions and catalyst design. Researchers also explore its potential in designing proton-conducting materials for fuel cells due to its acidic properties. In medicinal chemistry, it serves as a scaffold for developing enzyme inhibitors targeting sulfonamide-sensitive pathways.

Safety and Hazards

GHS Hazard Statements

• H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (66.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.