Description

4-Fluoro-3-formyl-5-methylphenylboronic acid (CAS No. 1310384-23-6) is a high-purity boronic acid derivative with the molecular formula C₈H₈BFO₃. This compound features a reactive boronic acid group (-B(OH)₂) adjacent to a formyl (-CHO) and a fluoro (-F) substituent on a methyl-substituted aromatic ring, making it a versatile building block for Suzuki-Miyaura cross-coupling reactions and other organoboron-mediated transformations. Its IUPAC name is (4-fluoro-3-formyl-5-methylphenyl)boronic acid, and it is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC). Ideal for pharmaceutical, agrochemical, and materials science research, this reagent is packaged under inert conditions to ensure stability. Store at 2-8°C in a dry environment. Synonyms include MFCD11111909 and Boronic acid, B-(4-fluoro-3-formyl-5-methylphenyl)-.

Properties

• CAS Number: 1310384-23-6
• Complexity: 188
• IUPAC Name: (4-fluoro-3-formyl-5-methyl-phenyl)boronic acid
• InChI: InChI=1S/C8H8BFO3/c1-5-2-7(9(12)13)3-6(4-11)8(5)10/h2-4,12-13H,1H3
• InChI Key: CYTRJUULLDUDAX-UHFFFAOYSA-N
• Exact Mass: 182.0550524
• Molecular Formula: C8H8BFO3
• Molecular Weight: 181.96
• SMILES: B(C1=CC(=C(C(=C1)C=O)F)C)(O)O
• Topological: 57.5
• Monoisotopic Mass: 182.0550524
• Synonyms: 1310384-23-6, 4-FLUORO-3-FORMYL-5-METHYLPHENYLBORONIC ACID, (4-Fluoro-3-formyl-5-methylphenyl)boronic acid, Boronic acid, B-(4-fluoro-3-formyl-5-methylphenyl)-, MFCD11111909, AKOS006309581, BS-20468, DB-218911, CS-0174808, (4-Fluoro-3-formyl-5-methylphenyl)boronicacid, D71471, (4-Fluoro-3-formyl-5-methyl-phenyl)boronic acid, 4-fluoro-3-formyl-5-methylphenylboronic acid, AldrichCPR

Application

4-Fluoro-3-formyl-5-methylphenylboronic acid is widely used as a key intermediate in palladium-catalyzed cross-coupling reactions to synthesize biaryl compounds for drug discovery. Its formyl group enables further functionalization via condensation or reduction, while the fluorine atom enhances metabolic stability in bioactive molecules. Researchers employ it in the development of fluorescent probes and polymeric materials due to its unique electronic properties. Suitable for high-throughput screening in medicinal chemistry.

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