Description

4-Fluoro-2-nitroaniline (CAS No. 364-78-3) is a high-purity nitroaniline derivative with the molecular formula C₆H₅FN₂O₂. This fine chemical is characterized by its yellow crystalline appearance and is widely utilized in organic synthesis, pharmaceutical research, and dye manufacturing. With an IUPAC name of 4-fluoro-2-nitroaniline, this compound offers exceptional reactivity due to the presence of both electron-withdrawing nitro and fluorine groups, making it a valuable intermediate for nucleophilic substitution and coupling reactions. Our product is rigorously tested for purity (typically ≥98% by HPLC or GC analysis) and is supplied in securely sealed packaging to ensure stability and longevity. Ideal for researchers and industrial scientists seeking reliable building blocks for heterocyclic chemistry and advanced material development.

Properties

• CAS Number: 364-78-3
• Complexity: 159
• IUPAC Name: 4-fluoro-2-nitro-aniline
• InChI: InChI=1S/C6H5FN2O2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H,8H2
• InChI Key: PUGDHSSOXPHLPT-UHFFFAOYSA-N
• Exact Mass: 156.03350557
• Molecular Formula: C6H5FN2O2
• Molecular Weight: 156.11
• SMILES: C1=CC(=C(C=C1F)[N+](=O)[O-])N
• Topological: 71.8
• Monoisotopic Mass: 156.03350557
• Synonyms: 4-Fluoro-2-nitroaniline, 364-78-3, Benzenamine, 4-fluoro-2-nitro-, EINECS 206-666-0, PUGDHSSOXPHLPT-UHFFFAOYSA-, DTXSID20189922, NSC 402980, DTXCID80112413, 206-666-0, inchi=1/c6h5fn2o2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3h,8h2, pugdhssoxphlpt-uhfffaoysa-n, 2-nitro-4-fluoroaniline, 4-Fluoro-2-nitrobenzeneamine, 4-FLUORO-2-NITROBENZENAMINE, 4-Fluoro-2-nitrophenylamine, MFCD00007830, 4-Fluoro-2-nitrioaniline, 4-Fluoro-2-nitro-phenylamine, Aniline, 4-fluoro-2-nitro-, NSC-402980, 2-Amino-5-fluoronitrobenzene, 4-fluoro-2-nitro-aniline, NSC402980, 2-nitro 4-fluro-aniline, 2-nitro 4-fluoro-aniline, 2-nitro-4-fluoro aniline, 2-nitro-4-fluoro-aniline, 3ETQ4SN24P, 4-Fluoro-2-nitrophenyl-amine, SCHEMBL537892, (4-fluoro-2-nitrophenyl)amine, CHEMBL4556558, 4-Fluoro-2-nitroaniline, 97%, BCP05910, SBB016897, STL197500, AKOS000119362, AC-3693, CS-W014364, DS-1187, FF61449, SB76037, BP-20100, SY007215, DB-023932, F0380, NS00041706, ST45025144, EN300-18234, Z57473881, F0001-2720

Application

4-Fluoro-2-nitroaniline serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty dyes. Its reactive nitro and amine groups facilitate the production of benzimidazole and quinoxaline derivatives. The compound is also employed in polymer chemistry as a cross-linking agent and in the development of fluorescent probes for biochemical assays.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.