Description

4-Fluoro-2-methylaniline (CAS No. 452-71-1) is a high-purity fluorinated aromatic amine with the molecular formula C₇H₈FN. This compound, also known as 4-Fluoro-o-toluidine, is a valuable intermediate in organic synthesis and pharmaceutical research. Its structure features a fluorine substituent at the para position and a methyl group at the ortho position relative to the amino group, offering unique reactivity for electrophilic substitution and coupling reactions.

Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied as a clear to pale yellow liquid with a characteristic amine odor. It is packaged under inert gas to prevent oxidation and degradation, ensuring optimal shelf life. Suitable for use in HPLC, LC-MS, and synthetic chemistry applications, this reagent is ideal for researchers developing fluorinated pharmaceuticals, agrochemicals, or advanced materials.

Key applications include use as a building block for triazole, benzimidazole, and quinazoline derivatives, as well as a precursor for dyes and liquid crystals. Store in a cool, dry place away from light and oxidizing agents.

Properties

• CAS Number: 452-71-1
• Complexity: 94.9
• IUPAC Name: 4-fluoro-2-methyl-aniline
• InChI: InChI=1S/C7H8FN/c1-5-4-6(8)2-3-7(5)9/h2-4H,9H2,1H3
• InChI Key: KMHLGVTVACLEJE-UHFFFAOYSA-N
• Exact Mass: 125.064077422
• Molecular Formula: C7H8FN
• Molecular Weight: 125.14
• SMILES: CC1=C(C=CC(=C1)F)N
• Topological: 26
• Monoisotopic Mass: 125.064077422
• Synonyms: 4-Fluoro-2-methylaniline, Benzenamine, 4-fluoro-2-methyl-, 4-Fluorotoluidine, 4-Fluoro-o-toluidine, 3-Fluoro-6-aminotoluene, P7D3BF9SJM, EINECS 207-208-2, NSC 88300, BRN 1931798, NSC-88300, DTXSID6060008, 4-12-00-01786 (Beilstein Handbook Reference), DTXCID9040390, 207-208-2, kmhlgvtvacleje-uhfffaoysa-n, 452-71-1, 2-Amino-5-fluorotoluene, 4-Fluoro-2-methylbenzenamine, 6-Amino-3-fluorotoluene, o-Toluidine, 4-fluoro-, 2-Methyl-4-fluoroaniline, 4-fluoro-2-methyl-aniline, MFCD00007832, 4-fluoro-2-methylphenylamine, 2-Amino -5-fluorotoluene, 4-Fluoro-2-methyl-phenylamine, NSC88300, 4-Fluor-o-toluidin, 4-fluoro-2-toluidine, 4-fluor-2-methylaniline, UNII-P7D3BF9SJM, 4-flouro-2-methylaniline, 4-fluoro-2-methyl aniline, NCIOpen2_001405, SCHEMBL102467, SCHEMBL653334, 4-fluoro-2-methyl-benzenamine, (4-fluoro-2-methylphenyl)amine, 4-Fluoro-2-methylaniline, 96%, BCP24546, SBB028217, STL163420, AKOS000120538, AC-3690, CS-W011173, PS-9200, DB-024060, F0398, NS00043467, EN300-20973, 4-Fluoro-2-methylaniline;4-Fluoro-o-toluidine

Application

4-Fluoro-2-methylaniline serves as a versatile intermediate in the synthesis of fluorinated heterocycles, including antimicrobial and antitumor agents. It is employed in pharmaceutical research for modifying drug solubility and bioavailability via fluorine incorporation. The compound is also used in agrochemical production and as a coupling agent for specialty dyes.

Safety and Hazards

GHS Hazard Statements

• H302 (98%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (10.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H312 (89.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (98%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (89.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (10.2%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (98%)
• Acute Tox. 3 (10.2%)
• Acute Tox. 4 (89.8%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (98%)
• STOT SE 3 (89.8%)
• STOT RE 2 (10.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.