Description

4-Fluoro-1H-isoindoline hydrochloride (CAS No. 924305-06-6) is a high-purity organic compound with the molecular formula C8H9ClFN, widely utilized in pharmaceutical research and chemical synthesis. This hydrochloride salt of 4-fluoroisoindoline offers excellent solubility and stability, making it an ideal intermediate for the development of bioactive molecules, including drug candidates and agrochemicals. With a purity of ≥97%, this product is rigorously tested via HPLC, NMR, and mass spectrometry to ensure consistency and reliability for sensitive applications. Its unique fluorinated isoindoline structure enables versatile reactivity in heterocyclic chemistry, particularly in the construction of nitrogen-containing scaffolds. Packaged under inert conditions to prevent degradation, it is available in quantities ranging from milligrams to kilograms, catering to both laboratory-scale and industrial-scale needs.

Properties

• CAS Number: 924305-06-6
• Complexity: 126
• IUPAC Name: 4-fluoroisoindoline;hydrochloride
• InChI: InChI=1S/C8H8FN.ClH/c9-8-3-1-2-6-4-10-5-7(6)8;/h1-3,10H,4-5H2;1H
• InChI Key: MKNPYNGKUKUSFB-UHFFFAOYSA-N
• Exact Mass: 173.0407551
• Molecular Formula: C8H9ClFN
• Molecular Weight: 173.61
• SMILES: C1C2=C(CN1)C(=CC=C2)F.Cl
• Topological: 12
• Monoisotopic Mass: 173.0407551
• Synonyms: 4-Fluoro-1H-isoindoline hydrochloride, 619-606-7, 4-Fluoroisoindoline Hydrochloride, 924305-06-6, 4-FLUORO-ISOINDOLINE HCL, 4-Fluoro-2,3-dihydro-1H-isoindole hydrochloride, 4-Fluoroisoindoline, HCl, 4-fluoro-2,3-dihydro-1H-isoindole;hydrochloride, 4-Fluoroisoindolinehydrochloride, 4-fluoroisoindoline;hydrochloride, MFCD10700143, 4-Fluoroisoindoline HCl, SCHEMBL621622, DTXSID00655039, MKNPYNGKUKUSFB-UHFFFAOYSA-N, BCP22289, AKOS015900639, FF09998, MB08984, 4-Fluoroisoindoline hydrochloride, 97%, DS-13873, SY009750, CS-0002181, EN300-250157, 1H-Isoindole,4-fluoro-2,3-dihydro-, hydrochloride (1:1), 4-Fluoro-2,3-dihydro-1H-isoindole–hydrogen chloride (1/1)

4-Fluoro-1H-isoindoline hydrochloride serves as a key building block in medicinal chemistry for the synthesis of fluorinated heterocycles, which are critical in drug discovery for optimizing pharmacokinetic properties. It is employed in the development of central nervous system (CNS) targeting agents due to its ability to enhance blood-brain barrier penetration. Researchers also leverage its reactivity in palladium-catalyzed cross-coupling reactions to introduce fluorinated motifs into complex molecules. Additionally, this compound finds use in material science for designing fluorescent probes and functionalized polymers.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.