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Atomfair 4-Ethoxy-2,3-difluorophenol C8H8F2O2 CAS 126163-56-2

4-Ethoxy-2,3-difluorophenol (CAS No. 126163-56-2) is a high-purity fluorinated phenolic compound with the molecular formula C8H8F2O2. This specialized chemical features an ethoxy group at the para position and two fluorine atoms at the ortho and meta positions relative to the hydroxyl group, offering unique electronic and steric properties. With a molecular weight of 174.14 g/mol, it is a valuable building block for pharmaceutical intermediates, agrochemical synthesis, and advanced material research. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied in sealed, light-resistant containers under inert gas to maintain stability. Suitable for use in cross-coupling reactions, nucleophilic aromatic…

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Description

4-Ethoxy-2,3-difluorophenol (CAS No. 126163-56-2) is a high-purity fluorinated phenolic compound with the molecular formula C8H8F2O2. This specialized chemical features an ethoxy group at the para position and two fluorine atoms at the ortho and meta positions relative to the hydroxyl group, offering unique electronic and steric properties. With a molecular weight of 174.14 g/mol, it is a valuable building block for pharmaceutical intermediates, agrochemical synthesis, and advanced material research. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied in sealed, light-resistant containers under inert gas to maintain stability. Suitable for use in cross-coupling reactions, nucleophilic aromatic substitutions, and as a precursor for liquid crystal materials.

Properties

  • CAS Number: 126163-56-2
  • Complexity: 143
  • IUPAC Name: 4-ethoxy-2,3-difluoro-phenol
  • InChI: InChI=1S/C8H8F2O2/c1-2-12-6-4-3-5(11)7(9)8(6)10/h3-4,11H,2H2,1H3
  • InChI Key: PKIYFPSPIFCDDB-UHFFFAOYSA-N
  • Exact Mass: 174.04923582
  • Molecular Formula: C8H8F2O2
  • Molecular Weight: 174.14
  • SMILES: CCOC1=C(C(=C(C=C1)O)F)F
  • Topological: 29.5
  • Monoisotopic Mass: 174.04923582
  • Synonyms: 4-Ethoxy-2,3-difluorophenol, 126163-56-2, DTXSID40560996, DTXCID70511774, 678-797-5, 1-Hydroxy-4-ethoxy-2,3-difluorobenzene, Phenol, 4-ethoxy-2,3-difluoro-, 4-Ethoxy-2,3-difluorophenol,JRD, 4-Ethoxy-2,3-difluorophenol, JRD, MFCD07368025, 2,3-difluoro-4-ethoxyphenol, SCHEMBL423475, 4-ethoxy-2,3-difluoro-phenol, PKIYFPSPIFCDDB-UHFFFAOYSA-N, SBB088876, AKOS006282952, CS-W017519, DS-5734, AC-14523, EN300-7406540

Application

4-Ethoxy-2,3-difluorophenol serves as a key intermediate in the synthesis of bioactive molecules, particularly in pharmaceutical research where fluorinated aromatics enhance metabolic stability. Its electron-withdrawing fluorine atoms make it valuable for designing liquid crystal materials with tailored dielectric properties. The compound is also utilized in agrochemical development to modify pesticidal activity profiles.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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