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Atomfair 4-(Diphenylmethyl)-1-piperazineethanol Cetirizine alcohol C19H24N2O CAS 10527-64-7

4-(Diphenylmethyl)-1-piperazineethanol (CAS No. 10527-64-7) is a high-purity organic compound with the molecular formula C19H24N2O. This versatile intermediate, also known as Cetirizine alcohol, features a piperazineethanol backbone substituted with a benzhydryl group, making it valuable for pharmaceutical synthesis and research applications. With a molecular weight of 296.41 g/mol, this white to off-white crystalline powder offers excellent solubility in common organic solvents. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied with comprehensive analytical documentation including1H NMR, HPLC chromatograms, and mass spectrometry data. Ideal for medicinal chemistry, this building block is particularly relevant for antihistamine drug development and…

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Description

4-(Diphenylmethyl)-1-piperazineethanol (CAS No. 10527-64-7) is a high-purity organic compound with the molecular formula C19H24N2O. This versatile intermediate, also known as Cetirizine alcohol, features a piperazineethanol backbone substituted with a benzhydryl group, making it valuable for pharmaceutical synthesis and research applications. With a molecular weight of 296.41 g/mol, this white to off-white crystalline powder offers excellent solubility in common organic solvents. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied with comprehensive analytical documentation including 1H NMR, HPLC chromatograms, and mass spectrometry data. Ideal for medicinal chemistry, this building block is particularly relevant for antihistamine drug development and CNS-active compound research. Packaged under inert atmosphere in amber glass vials with PTFE-lined caps to ensure stability during storage and shipping.

Properties

  • CAS Number: 10527-64-7
  • Complexity: 285
  • IUPAC Name: 2-(4-benzhydrylpiperazin-1-yl)ethanol
  • InChI: InChI=1S/C19H24N2O/c22-16-15-20-11-13-21(14-12-20)19(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,19,22H,11-16H2
  • InChI Key: QEYZAHKHYSGDJK-UHFFFAOYSA-N
  • Exact Mass: 296.188863393
  • Molecular Formula: C19H24N2O
  • Molecular Weight: 296.4
  • SMILES: C1CN(CCN1CCO)C(C2=CC=CC=C2)C3=CC=CC=C3
  • Topological: 26.7
  • Monoisotopic Mass: 296.188863393
  • Synonyms: 10527-64-7, Cetirizine alcohol, 4-benzhydryl-1-piperazineethanol, 1-Piperazineethanol, 4-(diphenylmethyl)-, 9AMR7XC6Q8, 4-(Diphenylmethyl)-1-piperazineethanol, 2-(4-benzhydrylpiperazin-1-yl)ethanol, 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine, UNII-9AMR7XC6Q8, 2-(4-benzhydrylpiperazin-1-yl)ethan-1-ol, 2-[4-(diphenylmethyl)piperazin-1-yl]ethan-1-ol, CETIRIZINE IMPURITY 46, SCHEMBL1491229, SCHEMBL7381083, SCHEMBL8629042, CHEMBL1254795, QEYZAHKHYSGDJK-UHFFFAOYSA-N, DTXSID401283035, MFCD06742676, AKOS003588739, 2-(4-benzhydryl piperazine-1-yl)ethanol, 2-(4-benzhydryl piperazine-1-yl) ethanol, DB-337187, G87516, A1-50250

Application

4-(Diphenylmethyl)-1-piperazineethanol serves as a key intermediate in the synthesis of second-generation antihistamines, particularly cetirizine derivatives. Researchers utilize this compound in developing novel histamine H1-receptor antagonists with reduced sedative effects. The benzhydryl-piperazine structure makes it valuable for studying structure-activity relationships in CNS-targeting pharmaceuticals. Additionally, it finds application in the preparation of zwitterionic compounds for improved blood-brain barrier penetration studies.

Safety and Hazards

GHS Hazard Statements

  • H225 (20%): Highly Flammable liquid and vapor [Danger Flammable liquids]
  • H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
  • H304 (20%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]
  • H315 (20%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H336 (20%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
  • H361 (20%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
  • H373 (20%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

  • P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P318, P319, P321, P330, P331, P332+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

  • Flam. Liq. 2 (20%)
  • Acute Tox. 3 (100%)
  • Asp. Tox. 1 (20%)
  • Skin Irrit. 2 (20%)
  • STOT SE 3 (20%)
  • Repr. 1B (20%)
  • STOT RE 2 (20%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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