Description

4-(Difluoromethoxy)aniline (CAS No. 22236-10-8) is a high-purity aromatic amine derivative featuring a difluoromethoxy functional group. With the molecular formula C₇H₇F₂NO, this compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structural properties make it ideal for the development of fluorine-containing compounds, which are known for their enhanced metabolic stability and bioavailability. This product is rigorously tested for quality and purity, ensuring reliable performance in sensitive applications. Suitable for researchers and industrial scientists, it is available in various packaging options to meet laboratory-scale and bulk requirements.

Properties

• CAS Number: 22236-10-8
• Complexity: 113
• IUPAC Name: 4-(difluoromethoxy)aniline
• InChI: InChI=1S/C7H7F2NO/c8-7(9)11-6-3-1-5(10)2-4-6/h1-4,7H,10H2
• InChI Key: NDEZTSHWEPQVBX-UHFFFAOYSA-N
• Exact Mass: 159.04957017
• Molecular Formula: C7H7F2NO
• Molecular Weight: 159.13
• SMILES: C1=CC(=CC=C1N)OC(F)F
• Topological: 35.3
• Monoisotopic Mass: 159.04957017
• Synonyms: 4-(Difluoromethoxy)aniline, 22236-10-8, DTXSID30353233, DTXCID40304296, 625-478-3, 4-difluoromethoxyaniline, 4-Difluoromethoxy-phenylamine, p-difluoromethoxyaniline, MFCD00085005, EN300-02436, 4-(difluoromethoxy)phenylamine, Benzenamine, 4-(difluoromethoxy)-, 4-Amino-alpha,alpha-difluoroanisole, 1-Bromo-4-(difluoromethyloxy)benzene, 4-difluoromethoxy aniline, 4-(difluoromethoxy)-aniline, SCHEMBL111632, 4-(difluoromethoxy)benzenamine, alpha,alpha-Difluoro-p-anisidine, [4-[Difluoromethoxy)phenyl]amine, ZMGFELPGEWDNQQ-UHFFFAOYSA-N, 4-(Difluoromethoxy)aniline, 98%, BDBM625945, HMS1782P18, ALBB-000305, BBL038040, SBB003981, STK346979, AKOS000104402, AC-2522, CS-W016186, FD38199, PS-8791, SB76536, SY001808, D3457, ST45123289, Z56899041, F5608-0059

Application

4-(Difluoromethoxy)aniline serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, including potential active ingredients for CNS and cardiovascular therapies. It is also utilized in agrochemical research for developing novel pesticides and herbicides with improved efficacy. The compound’s difluoromethoxy group enhances lipophilicity, making it valuable in medicinal chemistry for optimizing drug candidates.

Safety and Hazards

GHS Hazard Statements

• H301 (89.6%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (10.4%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (10.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (10.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (89.6%)
• Acute Tox. 4 (10.4%)
• Acute Tox. 4 (10.4%)
• Skin Irrit. 2 (97.9%)
• Eye Irrit. 2 (97.9%)
• Acute Tox. 4 (10.4%)
• STOT SE 3 (87.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.