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Atomfair 4-Cyclopropylpyrimidin-2-amine C7H9N3 CAS 21573-15-9

4-Cyclopropylpyrimidin-2-amine (CAS No. 21573-15-9) is a high-purity heterocyclic organic compound with the molecular formula C7H9N3. This pyrimidine derivative features a cyclopropyl substituent at the 4-position and an amino group at the 2-position, making it a valuable intermediate in pharmaceutical and agrochemical research. Its rigid cyclopropyl ring enhances metabolic stability, while the pyrimidine core offers versatile reactivity for further functionalization. Ideal for medicinal chemistry, this compound is supplied as a fine white to off-white crystalline powder with ≥95% purity (HPLC). Suitable for Suzuki couplings, nucleophilic substitutions, and other cross-coupling reactions. Packaged under inert gas to ensure stability and shipped with comprehensive…

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Description

4-Cyclopropylpyrimidin-2-amine (CAS No. 21573-15-9) is a high-purity heterocyclic organic compound with the molecular formula C7H9N3. This pyrimidine derivative features a cyclopropyl substituent at the 4-position and an amino group at the 2-position, making it a valuable intermediate in pharmaceutical and agrochemical research. Its rigid cyclopropyl ring enhances metabolic stability, while the pyrimidine core offers versatile reactivity for further functionalization. Ideal for medicinal chemistry, this compound is supplied as a fine white to off-white crystalline powder with ≥95% purity (HPLC). Suitable for Suzuki couplings, nucleophilic substitutions, and other cross-coupling reactions. Packaged under inert gas to ensure stability and shipped with comprehensive analytical data (NMR, MS, HPLC).

Properties

  • CAS Number: 21573-15-9
  • Complexity: 122
  • IUPAC Name: 4-cyclopropylpyrimidin-2-amine
  • InChI: InChI=1S/C7H9N3/c8-7-9-4-3-6(10-7)5-1-2-5/h3-5H,1-2H2,(H2,8,9,10)
  • InChI Key: WSRWIOBLJDEDRM-UHFFFAOYSA-N
  • Exact Mass: 135.079647300
  • Molecular Formula: C7H9N3
  • Molecular Weight: 135.17
  • SMILES: C1CC1C2=NC(=NC=C2)N
  • Topological: 51.8
  • Monoisotopic Mass: 135.079647300
  • Synonyms: 4-cyclopropylpyrimidin-2-amine, 21573-15-9, DTXSID40391207, DTXCID50342068, 843-538-9, 4-cyclopropyl-2-pyrimidinamine, 2-Pyrimidinamine, 4-cyclopropyl- (9CI), 2-AMINO-4-(CYCLOPROPYL)PYRIMIDINE, 4-cyclopropylpyrimidine-2-ylamine, 4-Cyclopropyl-pyrimidin-2-ylamine, MFCD03787899, SCHEMBL2036795, SBB085901, STL177342, AKOS004104847, AT12433, FA44328, DB-066558, CS-0215940, ST45084597, EN300-313223, 8T-0217, Z991536704

Application

4-Cyclopropylpyrimidin-2-amine serves as a key building block in the synthesis of kinase inhibitors and antiviral agents, particularly in the development of targeted therapies. Its structural motif is frequently employed in fragment-based drug discovery (FBDD) due to its balanced lipophilicity and hydrogen-bonding capacity. Researchers also utilize it to explore structure-activity relationships (SAR) in cyclopropyl-containing bioactive molecules. The compound’s stability under physiological conditions makes it suitable for in vitro and in vivo studies.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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