Description

(4-Cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid (CAS No. 1798304-51-4) is a high-purity boronic acid derivative with the molecular formula C₈H₁₁BN₂O₃. This specialized compound features a cyclopropyl and methoxy-substituted pyrimidine core, making it a valuable building block for Suzuki-Miyaura cross-coupling reactions in pharmaceutical and agrochemical research. Its boronic acid functional group enables efficient carbon-carbon bond formation, particularly in the synthesis of complex heterocyclic scaffolds. The product is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring optimal performance in demanding synthetic applications. Proper storage under inert conditions (2-8°C, argon atmosphere) is recommended to maintain stability.

Properties

• CAS Number: 1798304-51-4
• Complexity: 201
• IUPAC Name: (4-cyclopropyl-6-methoxy-pyrimidin-5-yl)boronic acid
• InChI: InChI=1S/C8H11BN2O3/c1-14-8-6(9(12)13)7(5-2-3-5)10-4-11-8/h4-5,12-13H,2-3H2,1H3
• InChI Key: BYXHEUWWJYYRNH-UHFFFAOYSA-N
• Exact Mass: 194.0862724
• Molecular Formula: C8H11BN2O3
• Molecular Weight: 194.00
• SMILES: B(C1=C(N=CN=C1OC)C2CC2)(O)O
• Topological: 75.5
• Monoisotopic Mass: 194.0862724
• Synonyms: (4-Cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid, 1798304-51-4, (4-Cyclopropyl-6-methoxy-pyrimidin-5-yl)boronic acid, MFCD31556945, (4-Cyclopropyl-6-methoxypyrimidin-5-yl)boronicacid, 4-Cyclopropyl-6-methoxypyrimidine-5-boronic Acid, SCHEMBL17168949, SY297089, WS-00856, DB-156954, CS-0435474, B-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)boronic acid

Application

This boronic acid derivative serves as a key intermediate in medicinal chemistry for constructing pyrimidine-based drug candidates, particularly kinase inhibitors. It enables the synthesis of novel compounds for oncology and antiviral research through palladium-catalyzed coupling reactions. The cyclopropyl moiety enhances metabolic stability in resulting molecules, making it valuable for lead optimization.

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