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Atomfair 4-Cyclopropyl-6-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine AT22463, DB-426518 C14H21BN2O3

Description 4-Cyclopropyl-6-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (CAS: 2750602-14-1) is a high-purity boronic ester derivative designed for advanced synthetic and medicinal chemistry applications. With the molecular formula C14H21BN2O3, this compound features a pyrimidine core functionalized with a cyclopropyl group, a methoxy substituent, and a pinacol boronate moiety, making it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions. Its stable dioxaborolane ring ensures excellent shelf life and handling convenience. Ideal for researchers developing novel pharmaceuticals, agrochemicals, or materials science applications, this compound is supplied with comprehensive analytical data (including1H NMR,13C NMR, and HPLC) to guarantee quality and reproducibility. Store under inert conditions at -20??C for prolonged stability.

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Description

Description

4-Cyclopropyl-6-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (CAS: 2750602-14-1) is a high-purity boronic ester derivative designed for advanced synthetic and medicinal chemistry applications. With the molecular formula C14H21BN2O3, this compound features a pyrimidine core functionalized with a cyclopropyl group, a methoxy substituent, and a pinacol boronate moiety, making it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions. Its stable dioxaborolane ring ensures excellent shelf life and handling convenience. Ideal for researchers developing novel pharmaceuticals, agrochemicals, or materials science applications, this compound is supplied with comprehensive analytical data (including 1H NMR, 13C NMR, and HPLC) to guarantee quality and reproducibility. Store under inert conditions at -20??C for prolonged stability.

  • CAS No: 2750602-14-1
  • Molecular Formula: C14H21BN2O3
  • Molecular Weight: 276.14
  • Exact Mass: 276.1645227
  • Monoisotopic Mass: 276.1645227
  • IUPAC Name: 4-cyclopropyl-6-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=C(N=CN=C2OC)C3CC3
  • Synonyms: 2750602-14-1, 4-Cyclopropyl-6-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine, AT22463, DB-426518, (4-CYCLOPROPYL-6-METHOXYPYRIMIDIN-5-YL)BORONIC ACID PINACOL ESTER

Application

This boronic ester is primarily employed in palladium-catalyzed cross-coupling reactions to construct biaryl or heteroaryl systems prevalent in drug discovery. Its pyrimidine scaffold is particularly valuable for modifying nucleoside analogs or kinase inhibitors. The cyclopropyl group enhances metabolic stability in medicinal chemistry candidates, while the pinacol boronate offers superior reactivity in aqueous conditions compared to boronic acids. Common applications include synthesizing intermediates for antiviral, anticancer, or CNS-targeted small molecules.

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