Description

(4-Chlorophenyl)magnesium bromide (CAS No. 873-77-8) is a highly reactive Grignard reagent with the molecular formula C₆H₄BrClMg. This organomagnesium compound is widely used in synthetic organic chemistry for nucleophilic addition reactions due to its ability to form carbon-carbon bonds efficiently. Supplied as a solution in common solvents such as diethyl ether or tetrahydrofuran (THF), it is moisture-sensitive and must be handled under inert conditions (e.g., nitrogen or argon atmosphere). Ideal for researchers and industrial chemists, this reagent is rigorously tested for purity and consistency, ensuring optimal performance in complex synthesis applications. Store in tightly sealed containers at recommended temperatures to maintain stability.

Properties

• CAS Number: 873-77-8
• Complexity: 133
• IUPAC Name: magnesium;chlorobenzene;bromide
• InChI: InChI=1S/C6H4Cl.BrH.Mg/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q-1;;+2/p-1
• InChI Key: DLJIPJMUYCUTOV-UHFFFAOYSA-M
• Exact Mass: 213.90353
• Molecular Formula: C6H4BrClMg
• Molecular Weight: 215.76
• SMILES: C1=CC(=CC=[C-]1)Cl.[Mg+2].[Br-]
• Monoisotopic Mass: 213.90353
• Synonyms: (4-chlorophenyl)magnesium bromide, Bromo(p-chlorophenyl)magnesium, EINECS 212-853-8, DTXSID301299786, DTXCID501729923, 212-853-8, 873-77-8, 4-chlorophenylmagnesium bromide, 4-Chlorophenylmagnesium bromide, 1.0 M in THF, magnesium;chlorobenzene;bromide, MFCD00009926, 4-Chlorophenylmagnesium bromide, 1M in MeTHF, 4-Chlorophenylmagnesium bromide 0.5 M in Tetrahydrofuran, 73-77-8, p-chlorophenylmagnesium bromide, 4-chlorophenyl magnesium bromide, 4-chlorophenylmagnesiumbromide, 4-chlorphenylmagnesium bromide, SCHEMBL181194, 4-chloro phenylmagnesiumbromide, 4-chlorophenyhnagnesium bromide, 4-chlorophenyl magnesiumbromide, 4-chlorophenyl-magnesiumbromide, 4-Chlorophenylmagnesium bromide, 1.0 M in 2-MeTHF, Bromo(4-chlorophenyl)magnesium, 4-Chloro-phenylmagnesiumbromide, p-chlorophenyl magnesium bromide, bromo-(-4chlorophenyl)magnesium, 4-chloro phenylmagnesium bromide, 4-chlorophenyl-magnesium bromide, CDEMHJCJMMOFMB-UHFFFAOYSA-M, (4-chlorophenyl)-magnesium bromide, AKOS015890252, 4-Chlorophenylmagnesium bromide 1M in THF, NS00079947, 4-Chlorophenylmagnesium bromide 1.0 M in diethylether, 4-Chlorophenylmagnesium bromide 1.0 M in diethyl ether

Application

(4-Chlorophenyl)magnesium bromide is primarily employed in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals via Grignard reactions. It serves as a key intermediate for introducing the 4-chlorophenyl group into target molecules through nucleophilic additions to carbonyl compounds (e.g., ketones, aldehydes). Its applications extend to cross-coupling reactions and the preparation of liquid crystals or advanced materials. Strict exclusion of air and moisture is critical during use.

Safety and Hazards

GHS Hazard Statements

• H225 (43.8%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (43.8%)
• Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.