Description

4-(Chlorodifluoromethoxy)aniline (CAS: 39065-95-7) is a high-purity specialty chemical designed for advanced research and industrial applications. With the molecular formula C₇H₆ClF₂NO, this compound features a chlorodifluoromethoxy group attached to an aniline moiety, making it a versatile intermediate in organic synthesis and pharmaceutical development. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied in sealed, light-resistant packaging to maintain stability. Ideal for use in cross-coupling reactions, fluorination studies, and agrochemical research, this compound is a critical building block for scientists exploring novel chemical entities. Available in quantities from 1g to 1kg, with custom bulk options upon request.

Properties

• CAS Number: 39065-95-7
• Complexity: 148
• IUPAC Name: 4-[chloro(difluoro)methoxy]aniline
• InChI: InChI=1S/C7H6ClF2NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2
• InChI Key: QDTUQGSYECRXDO-UHFFFAOYSA-N
• Exact Mass: 193.0105978
• Molecular Formula: C7H6ClF2NO
• Molecular Weight: 193.58
• SMILES: C1=CC(=CC=C1N)OC(F)(F)Cl
• Topological: 35.3
• Monoisotopic Mass: 193.0105978
• Synonyms: 4-(chlorodifluoromethoxy)aniline, 39065-95-7, DTXSID70341396, DTXCID90292477, 639-301-2, 4-[Chloro(difluoro)methoxy]aniline, 4-(Chloro-difluoro-methoxy)-phenylamine, 4-chlorodifluoromethoxyaniline, MFCD01820809, 4-(chlorodifluoromethoxy)phenylamine, Benzenamine, 4-(chlorodifluoromethoxy)-, 4-(Difluorochloromethoxy)aniline; 4-(chlorodifluoromethoxy)benzenamine; 4-(Chloro-difluoro-methoxy)-phenylamine, SCHEMBL8812561, 4-(chlorodifluoromethoxy)-aniline, 4-(chloro-difluoro-methoxy)aniline, SBB000319, STK675869, Benzenamine, 4-chlorodifluoromethoxy-, 4-(chloro-difluoro-methoxy)phenylamine, 4-[Chloro(difluoro)methoxy]aniline #, AKOS005593927, CS-W000678, FC84861, DS-12457, ST044792, SY106667, 4-(CHLORODIFLUOROMETHOXY)BENZENAMINE, F31353, EN300-5234384, 4-(chloro-difluoro-methoxy)-phenylamine, AldrichCPR

4-(Chlorodifluoromethoxy)aniline serves as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its unique structure enables participation in palladium-catalyzed cross-coupling reactions for drug discovery. Researchers also utilize it to develop advanced materials with tailored electronic properties. The compound’s stability under acidic conditions makes it suitable for multi-step synthetic routes.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (50%)
• Eye Irrit. 2 (50%)
• Acute Tox. 4 (50%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.