Atomfair 4-Chlorobenzoyl Fluoride C7H4ClFO CAS 456-21-3

Description

4-Chlorobenzoyl Fluoride (CAS No. 456-21-3) is a high-purity organic compound with the molecular formula C₇H₄ClFO. This specialized reagent is widely used in pharmaceutical and agrochemical research as a key intermediate for synthesizing advanced molecules. The compound features a benzoyl fluoride backbone substituted with a chlorine group at the para position, offering unique reactivity in nucleophilic acyl substitution reactions. Our product is rigorously tested to ensure >98% purity (GC) and is supplied in sealed containers under inert atmosphere to maintain stability. Ideal for use in peptide coupling, cross-coupling reactions, and as a building block for liquid crystal materials. Available in quantities from grams to kilograms with custom packaging options upon request.

Properties

• CAS Number: 456-21-3
• Complexity: 130
• IUPAC Name: 4-chlorobenzoyl fluoride
• InChI: InChI=1S/C7H4ClFO/c8-6-3-1-5(2-4-6)7(9)10/h1-4H
• InChI Key: XUPDMYDJDICHJJ-UHFFFAOYSA-N
• Exact Mass: 157.9934706
• Molecular Formula: C7H4ClFO
• Molecular Weight: 158.56
• SMILES: C1=CC(=CC=C1C(=O)F)Cl
• Topological: 17.1
• Monoisotopic Mass: 157.9934706
• Synonyms: 4-chlorobenzoyl Fluoride, 456-21-3, 991-928-3, Benzoyl fluoride, 4-chloro-, 4-Chloro-benzoyl fluoride, SCHEMBL9834776, DTXSID90452918, MFCD22053313, HS-3427, G90026

Application

4-Chlorobenzoyl Fluoride serves as a versatile building block in organic synthesis, particularly in the preparation of pharmaceutical intermediates. It is commonly employed in peptide coupling reactions where the fluoride acts as an excellent leaving group. The compound also finds use in materials science for the synthesis of liquid crystal precursors and specialty polymers. Researchers utilize it in palladium-catalyzed cross-coupling reactions to create complex biaryl structures.

Safety and Hazards

GHS Hazard Statements

• H290 (100%): May be corrosive to metals [Warning Corrosive to Metals]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P234, P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P390, P405, P406, and P501

Hazard Classes and Categories

• Met. Corr. 1 (100%)
• Skin Corr. 1B (100%)
• Eye Dam. 1 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.