Description

4-Chlorobenzoyl chloride (CAS No. 122-01-0) is a highly reactive organic compound with the molecular formula C₇H₄Cl₂O. This aromatic acyl chloride is a clear to pale yellow liquid with a pungent odor, widely used as a key intermediate in organic synthesis and pharmaceutical manufacturing. Its IUPAC name is 4-chlorobenzoyl chloride, and it is also known by synonyms such as p-Chlorobenzoyl chloride and para-Chlorobenzoyl chloride. This compound is moisture-sensitive and should be stored under inert conditions to prevent hydrolysis. Ideal for researchers and chemists, our high-purity grade ensures consistent performance in reactions such as Friedel-Crafts acylation, peptide coupling, and the synthesis of agrochemicals, dyes, and active pharmaceutical ingredients (APIs).

Key Features:

• High purity (>98%) for reliable synthetic applications
• Moisture-sensitive – handle under nitrogen or argon
• Versatile acylating agent for nucleophiles (amines, alcohols)
• Compatible with Schlenk techniques and anhydrous conditions

Properties

• CAS Number: 122-01-0
• Complexity: 128
• IUPAC Name: 4-chlorobenzoyl chloride
• InChI: InChI=1S/C7H4Cl2O/c8-6-3-1-5(2-4-6)7(9)10/h1-4H
• InChI Key: RKIDDEGICSMIJA-UHFFFAOYSA-N
• Exact Mass: 173.9639201
• Molecular Formula: C7H4Cl2O
• Molecular Weight: 175.01
• SMILES: C1=CC(=CC=C1C(=O)Cl)Cl
• Topological: 17.1
• Monoisotopic Mass: 173.9639201
• Physical Description: Clear colorless liquid; mp = 12-14 deg C;
• Vapor Pressure: 0.05 [mmHg]
• Synonyms: 4-CHLOROBENZOYL CHLORIDE, 122-01-0, Benzoyl chloride, 4-chloro-, p-Chlorobenzoyl chloride, para-Chlorobenzoyl chloride, 4-Chlorobenzoic acid chloride, 8UQ7JCV2YP, EINECS 204-515-3, Benzoyl chloride, p-chloro-, CCRIS 8935, DTXSID4051619, AI3-14889, DTXCID9030171, CHEBI:60716, EC 204-515-3, pChlorobenzoylchlorid, pChlorobenzoyl chloride, Benzoyl chloride, 4chloro, 204-515-3, inchi=1/c7h4cl2o/c8-6-3-1-5(2-4-6)7(9)10/h1-4, rkiddegicsmija-uhfffaoysa-n, 4-chloro-benzoyl chloride, 4-Chlorobenzoylchloride, 4-chloro benzoyl chloride, 4-Chloro-benzoyl Chloride; p-Chloro-benzoyl Chloride; 4-Chlorobenzoic Acid Chloride; p-Chlorobenzoyl Chloride; para-Chlorobenzoyl Chloride, MFCD00000686, PCBOC, p-chlorobenzoylchloride, 4chlorobenzoyl chloride, p-Chlorobenzoyl cloride, p-chloro benzoylchloride, p-chloro-benzoylchloride, p-chlorobenzoyl chlorine, 4-chloro benzoylchloride, 4-chloro-benzoylchloride, 4-chlorobenzoyl-chloride, p-chloro-benzoyl chloride, rho-chlorobenzoyl chloride, UNII-8UQ7JCV2YP, SCHEMBL1854, p-chlorobenzoic acid chloride, 4-chlorophenylcarbonyl chloride, 4-Chlorobenzoyl chloride, 95%, 4-Chlorobenzoyl chloride, 99%, BCP28337, CS-M3728, STR00125, Tox21_303719, BBL011385, SBB058751, STL146486, AKOS005721048, NCGC00357032-01, CAS-122-01-0, FC159356, DB-041641, NS00003848, ST51037892, EN300-21335, Q17521019, F2190-0063

Application

4-Chlorobenzoyl chloride is primarily used as an acylating agent in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It serves as a precursor for the production of herbicides, dyes, and liquid crystal materials. In peptide chemistry, it is employed for the protection of amino groups. Additionally, it is utilized in Friedel-Crafts reactions to introduce the 4-chlorobenzoyl moiety into aromatic systems.

Safety and Hazards

GHS Hazard Statements

• Not Classified

Precautionary Statements

• P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (99.4%)
• Eye Dam. 1 (60.5%)
• STOT SE 3 (33.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.