Description

4-Chloro-3-(trifluoromethyl)aniline (CAS No. 320-51-4) is a high-purity aromatic amine derivative with the molecular formula C₇H₅ClF₃N. This compound features a chloro-substituted benzene ring with a trifluoromethyl group and an amino group at the meta and para positions, respectively, making it a versatile intermediate in organic synthesis and pharmaceutical applications. Its unique structural properties enable reactivity in electrophilic substitution and cross-coupling reactions. Available in >98% purity (HPLC), it is supplied as a crystalline solid with strict quality control to ensure consistency for research and industrial use. Ideal for use in Suzuki-Miyaura couplings, amidation reactions, and as a precursor for agrochemicals and pharmaceuticals. Store under inert conditions at 2-8°C to maintain stability.

Properties

• CAS Number: 320-51-4
• Complexity: 159
• IUPAC Name: 4-chloro-3-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H5ClF3N/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3H,12H2
• InChI Key: ASPDJZINBYYZRU-UHFFFAOYSA-N
• Exact Mass: 195.0062613
• Molecular Formula: C7H5ClF3N
• Molecular Weight: 195.57
• SMILES: C1=CC(=C(C=C1N)C(F)(F)F)Cl
• Topological: 26
• Monoisotopic Mass: 195.0062613
• Synonyms: 4-Chloro-3-(trifluoromethyl)aniline, 5-Amino-2-chlorobenzotrifluoride, 2-Chloro-5-aminobenzotrifluoride, Benzenamine, 4-chloro-3-(trifluoromethyl)-, 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine, 6-Chloro-3-aminobenzotrifluoride, CCRIS 2815, EINECS 206-277-6, NSC 61405, UNII-000N5814MR, CHEBI:59245, NSC-61405, 000N5814MR, DTXSID7059804, ASPDJZINBYYZRU-UHFFFAOYSA-, (4-CHLORO-3-TRIFLUOROMETHYLPHENYL)AMINE, 4-CHLORO-.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-TOLUIDINE, DTXCID7038442, aspdjzinbyyzru-uhfffaoysa-n, inchi=1/c7h5clf3n/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3h,12h2, 320-51-4, 3-(Trifluoromethyl)-4-chloroaniline, ACBT, 2-chloro-5-aminebenzotrifluoride, 4-chloro-3-(trifluoromethyl)benzenamine, 4-Chloro-3-trifluoromethylaniline, MFCD00007846, Aniline, 4-chloro-3-(trifluoromethyl)-, 4-Chloro-3-(trifluoromethyl) aniline, 4-Chloro-3-trifluoromethyl-phenylamine, Hydromorphone 3-Sulfate, 479081-35-1, m-Toluidine, 4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-, 4-chloro-3-(trifluoromethyl)phenylamine, (5a)-4,5-Epoxy-17-methyl-3-(sulfooxy)morphinan-6-one;, 4-Amino-1-chloro-2-(trifluoromethyl)benzene, NSC61405, m-Toluidine, 4-chloro-alpha,alpha,alpha-trifluoro-, 3-AMINO-6-CHLOROBENZOTRIFLUORIDE, Epitope ID:131789, SCHEMBL203216, SCHEMBL7470531, SCHEMBL9374081, SCHEMBL27582794, 3-triflouromethyl-4-chloroanilin, 4-chloro-5-trifluoromethylaniline, 3-Trifluoromethyl-4-chloroaniline, 5-amino-2-chloro-benzotrifluoride, HMS1648N05, 3-trifluoromethyl-4-chloro aniline, 3-trifluoromethyl-4-chloro-aniline, 4-chloro-3-trifluoromethyl aniline, 4-chloro-3-trifluoromethyl-aniline, BCP09443, p-chloro-m-(trifluoromethyl)aniline, 4-chloro-3 (trifluoromethyl)aniline, 4-chloro-3-trifluoro methyl aniline, 4-chloro-3-trifluoromethylbenzenamine, BBL018123, SBB003592, STK902087, 4-chloro-3-(trifluoromethyl)-aniline, 4-Chloro-3-trifluoromethylphenylamine, 4-chloro-a,a,a-trifluoro-m-toluidine, AKOS000120459, CS-W019997, PS-8279, 4-Chloro-3-(trifluoromethyl)benzeneamine, AC-25037, Benzenamine, 4-chloro-3-trifluoromethyl-, HY-77822, 4-chloro-3-(trifluoromethyl)benzene amine, 4-Chloro-3-(trifluoromethyl)aniline, 99%, A5768, NS00042292, ST45255325, EN300-20471, Q27126565, F2108-0227, Z104478336, 4-chloro-3-trifluoromethylaniline;4-Chloro-3-(trifluoromethyl)aniline; 4-Chloro-3-(trifluoromethyl)benzenamine; 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine;4-Chloro-3-(trifluoromethyl)-benzenamine

Application

4-Chloro-3-(trifluoromethyl)aniline is widely employed as a key intermediate in the synthesis of pharmaceuticals, particularly for bioactive molecules targeting CNS disorders and antimicrobial agents. Its trifluoromethyl group enhances lipophilicity, making it valuable in agrochemical development for herbicides and fungicides. Researchers also utilize it in material science for constructing fluorinated polymers with enhanced thermal and chemical resistance.

Safety and Hazards

GHS Hazard Statements

• H302 (78%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (11.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (98.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (11.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (89.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (78%)
• Acute Tox. 4 (11.9%)
• Skin Irrit. 2 (98.3%)
• Eye Irrit. 2 (98.3%)
• Acute Tox. 4 (11.9%)
• STOT SE 3 (89.8%)

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