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Atomfair [4-Chloro-3-(trifluoromethoxy)phenyl]boronic acid C7H5BClF3O3 CAS 902757-07-7

[4-Chloro-3-(trifluoromethoxy)phenyl]boronic acid (CAS No. 902757-07-7) is a high-purity boronic acid derivative with the molecular formula C7H5BClF3O3. This compound features a chloro-substituted phenyl ring and a trifluoromethoxy group, making it a versatile intermediate in organic synthesis and pharmaceutical research. It is particularly valuable in Suzuki-Miyaura cross-coupling reactions due to its stable boronic acid functionality, enabling the […]

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Description

[4-Chloro-3-(trifluoromethoxy)phenyl]boronic acid (CAS No. 902757-07-7) is a high-purity boronic acid derivative with the molecular formula C7H5BClF3O3. This compound features a chloro-substituted phenyl ring and a trifluoromethoxy group, making it a versatile intermediate in organic synthesis and pharmaceutical research. It is particularly valuable in Suzuki-Miyaura cross-coupling reactions due to its stable boronic acid functionality, enabling the formation of biaryl structures under mild conditions. The product is supplied as a white to off-white crystalline powder, rigorously tested for purity (typically ≥95% by HPLC or NMR), and stored under inert conditions to ensure stability. Suitable for use in medicinal chemistry, material science, and agrochemical development.

Properties

  • CAS Number: 902757-07-7
  • Complexity: 214
  • IUPAC Name: [4-chloro-3-(trifluoromethoxy)phenyl]boronic acid
  • InChI: InChI=1S/C7H5BClF3O3/c9-5-2-1-4(8(13)14)3-6(5)15-7(10,11)12/h1-3,13-14H
  • InChI Key: ZTIWEYMDQDWLHC-UHFFFAOYSA-N
  • Exact Mass: 239.9972364
  • Molecular Formula: C7H5BClF3O3
  • Molecular Weight: 240.37
  • SMILES: B(C1=CC(=C(C=C1)Cl)OC(F)(F)F)(O)O
  • Topological: 49.7
  • Monoisotopic Mass: 239.9972364
  • Synonyms: 902757-07-7, (4-Chloro-3-(trifluoromethoxy)phenyl)boronic acid, [4-Chloro-3-(trifluoromethoxy)phenyl]boronic acid, 846-263-2, 4-chloro-3-(trifluoromethoxy)phenylboronic acid, Boronic acid, [4-chloro-3-(trifluoromethoxy)phenyl]-, 4-Chloro-3-trifluoromethoxyphenylboronic acid, MFCD11040273, SCHEMBL2409490, CLB75707, AKOS027265183, 4Chloro3TrifluoromethoxyphenylboornicAcid, CS-15981, CS-0082117, 4-chloro-3-trifluoromethoxyphenyl boronic acid, EN300-267811, N13218, (4-Chloro-3-(trifluoromethoxy)phenyl)boronicacid, Z1509573020

Application

[4-Chloro-3-(trifluoromethoxy)phenyl]boronic acid is widely used as a key building block in Suzuki-Miyaura cross-coupling reactions to synthesize complex biaryl compounds for pharmaceutical and material science applications. Its trifluoromethoxy and chloro substituents enhance electron-withdrawing properties, making it valuable in designing bioactive molecules. Researchers also employ it in the development of liquid crystals and OLED materials due to its structural rigidity and halogenated motifs.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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