Description

4-Chloro-3-methoxyaniline (CAS No. 13726-14-2) is a high-purity organic compound with the molecular formula C₇H₈ClNO. This aromatic amine features a chloro-substituted methoxy aniline structure, making it a valuable intermediate in synthetic organic chemistry. Its IUPAC name, 4-chloro-3-methoxyaniline, reflects its precise molecular configuration. This compound is supplied as a fine powder or crystalline solid with consistent batch-to-batch quality, ideal for research and industrial applications. It is rigorously tested for purity (typically ≥98% by HPLC or GC analysis) and is packaged under inert conditions to ensure stability. Suitable for use in pharmaceuticals, agrochemicals, and dye synthesis, this chemical is handled in compliance with GHS standards and is available in quantities ranging from grams to kilograms.

Properties

• CAS Number: 13726-14-2
• Complexity: 110
• IUPAC Name: 4-chloro-3-methoxy-aniline
• InChI: InChI=1S/C7H8ClNO/c1-10-7-4-5(9)2-3-6(7)8/h2-4H,9H2,1H3
• InChI Key: LNKBDFVSILQKSI-UHFFFAOYSA-N
• Exact Mass: 157.0294416
• Molecular Formula: C7H8ClNO
• Molecular Weight: 157.60
• SMILES: COC1=C(C=CC(=C1)N)Cl
• Topological: 35.3
• Monoisotopic Mass: 157.0294416
• Synonyms: 4-Chloro-3-methoxyaniline, 13726-14-2, DTXSID10518242, DTXCID10469048, 677-654-4, 3-Methoxy-4-chloroaniline, Benzenamine, 4-chloro-3-methoxy-, 4-Chloro-m-anisidine, 2-Chloro-5-aminoanisole, 4-Chloro-3-methoxyphenylamine, 5-Amino-2-chloroanisole, MFCD00672967, 4-Chloro-3-Methoxy aniline, 4-chloro-3-methoxy-phenylamine, 2-chloro-5-amino anisole, 3-methoxy-4-chloro aniline, 4-chloro-3-methoxybenzenamine, SCHEMBL110433, 4-chloro-3-methoxybenzeneamine, 4-chloro-3-(methyloxy)aniline, 4-chloro-3-methoxy-benzenamine, SCHEMBL1808482, SCHEMBL11532083, CHEBI:188903, 1-Amino-4-chloro-3-methoxybenzene, BCP15300, SBB070068, AKOS005215994, AC-3730, CS-W016214, FC10737, PS-3401, SB76392, DB-358046, C1774, EN300-49205, Z586249876

Application

4-Chloro-3-methoxyaniline serves as a key building block in the synthesis of pharmaceuticals, particularly in the development of active pharmaceutical ingredients (APIs) with antimicrobial or antitumor properties. It is also utilized in agrochemical research for creating herbicides and pesticides due to its reactive aniline and chloro functional groups. Additionally, this compound finds application in dye and pigment manufacturing, where it acts as an intermediate for azo dyes and other colorants. Researchers value its versatility in coupling reactions and as a precursor for heterocyclic compounds.

Safety and Hazards

GHS Hazard Statements

• H301 (85.7%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (14.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (85.7%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H312 (14.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (28.6%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (14.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (14.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (57.1%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (85.7%)
• Acute Tox. 4 (14.3%)
• Acute Tox. 3 (85.7%)
• Acute Tox. 4 (14.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 3 (28.6%)
• Acute Tox. 4 (14.3%)
• STOT SE 3 (14.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.