Description

4-Chloro-3-fluorophenol (CAS: 348-60-7) is a high-purity halogenated phenol derivative with the molecular formula C₆H₄ClFO. This compound is widely utilized in organic synthesis, pharmaceutical intermediates, and agrochemical research due to its reactive phenolic hydroxyl group and halogen substituents. With a purity of ≥98%, it is ideal for precise laboratory applications, including coupling reactions, polymer synthesis, and as a building block for advanced materials. Packaged under inert conditions to ensure stability, this product meets stringent quality standards for researchers and industrial scientists. Available in various quantities with detailed technical specifications, including NMR, HPLC, and MSDS data upon request.

Properties

• CAS Number: 348-60-7
• Complexity: 99.1
• IUPAC Name: 4-chloro-3-fluoro-phenol
• InChI: InChI=1S/C6H4ClFO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H
• InChI Key: XLHYAEBESNFTCA-UHFFFAOYSA-N
• Exact Mass: 145.9934706
• Molecular Formula: C6H4ClFO
• Molecular Weight: 146.54
• SMILES: C1=CC(=C(C=C1O)F)Cl
• Topological: 20.2
• Monoisotopic Mass: 145.9934706
• Synonyms: 4-Chloro-3-fluorophenol, 348-60-7, DTXSID40369148, DTXCID50320184, 609-036-7, 3-Fluoro-4-chlorophenol, MFCD00042583, Phenol, 4-chloro-3-fluoro-, 3-fluoro-4-chloro phenol, 3-fluoro-4-chloro-phenol, SCHEMBL150261, SCHEMBL330665, SCHEMBL20240829, SCHEMBL29183750, 4-Chloro-3-fluorophenol, 98%, SBB086512, AKOS005258409, AC-3775, CS-W007652, PS-8944, SY021811, C2476, NS00126649, ST50824047, EN300-114601, InChI=1/C6H4ClFO/c7-5-2-1-4(9)3-6(5)8/h1-3,9

4-Chloro-3-fluorophenol serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Its halogenated structure enables nucleophilic substitution reactions, making it valuable for creating complex molecular architectures. Researchers also employ it in material science for modifying polymer properties. Handle with standard safety precautions for halogenated phenols.

Safety and Hazards

GHS Hazard Statements

• H302 (13%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (13%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (91.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (91.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (89.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (13%)
• Acute Tox. 4 (13%)
• Skin Irrit. 2 (91.3%)
• Eye Irrit. 2 (91.3%)
• STOT SE 3 (89.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.