Description

4-Chloro-3-fluoroaniline (CAS No. 367-22-6) is a high-purity organic compound with the molecular formula C₆H₅ClFN, widely utilized in pharmaceutical and agrochemical research. This halogenated aniline derivative serves as a crucial intermediate in the synthesis of active pharmaceutical ingredients (APIs), dyes, and specialty chemicals. With a purity of ≥97.0% (GC), our product ensures consistent performance in demanding applications. Its unique combination of chloro and fluoro substituents enhances reactivity and selectivity in electrophilic aromatic substitution reactions. Packaged under inert atmosphere to prevent degradation, this compound is ideal for researchers requiring precise and reliable building blocks for complex molecular architectures.

Properties

• CAS Number: 367-22-6
• Complexity: 99.1
• IUPAC Name: 4-chloro-3-fluoro-aniline
• InChI: InChI=1S/C6H5ClFN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2
• InChI Key: ACMJJQYSPUPMPN-UHFFFAOYSA-N
• Exact Mass: 145.0094550
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.56
• SMILES: C1=CC(=C(C=C1N)F)Cl
• Topological: 26
• Monoisotopic Mass: 145.0094550
• Synonyms: 4-Chloro-3-fluoroaniline, 367-22-6, 4-chloro-3-fluorobenzenamine, EINECS 206-683-3, DTXSID20190139, DTXCID80112630, 206-683-3, 3-Fluoro-4-Chloroaniline, Benzenamine, 4-chloro-3-fluoro-, 4-chloro-3-fluorophenylamine, MFCD01090987, 4-Chloro-3-fluoroanline, 4-Chloro-3-fluoro-phenylamine, 5B8GP7SE8E, SCHEMBL240923, Aniline, 4-chloro-3-fluoro-, SCHEMBL21000942, SCHEMBL27906692, SBB069989, STL195580, AKOS005255237, AB08243, AC-3669, CS-W002747, FC34022, PS-8954, DB-023936, C2512, NS00041710, 4-Chloro-3-fluoroaniline, >=97.0% (GC), EN300-39518, F0001-1050, Z382694754

4-Chloro-3-fluoroaniline is primarily employed as a versatile intermediate in pharmaceutical synthesis, particularly for fluorinated drug candidates. It finds use in agrochemical production for creating herbicides and pesticides with enhanced activity. Researchers also utilize it in material science for developing advanced polymers and dyes. Its halogenated structure makes it valuable in cross-coupling reactions and as a precursor for heterocyclic compounds.

Safety and Hazards

GHS Hazard Statements

• H302 (96.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (96.1%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (94.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (94.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (88.2%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (11.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (84.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (96.1%)
• Acute Tox. 3 (96.1%)
• Skin Irrit. 2 (94.1%)
• Eye Irrit. 2 (94.1%)
• Acute Tox. 3 (88.2%)
• Acute Tox. 4 (11.8%)
• STOT SE 3 (84.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.