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Atomfair 4-Chloro-2,5-difluorobenzonitrile C7H2ClF2N CAS 135748-35-5

4-Chloro-2,5-difluorobenzonitrile (CAS No. 135748-35-5) is a high-purity fluorinated aromatic nitrile compound with the molecular formula C7H2ClF2N . This versatile intermediate features a chloro and two fluoro substituents on the benzene ring, offering unique reactivity for nucleophilic aromatic substitution and cross-coupling reactions. With a molecular weight of 173.55 g/mol, this white to off-white crystalline solid is ideal for pharmaceutical synthesis, agrochemical development, and advanced material applications. Packaged under inert gas to ensure stability, our product is rigorously tested by HPLC/GC to guarantee ≥98% purity. Suitable for research scale to kilo-lab production, it is supplied in amber glass bottles with PTFE-lined caps…

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Description

4-Chloro-2,5-difluorobenzonitrile (CAS No. 135748-35-5) is a high-purity fluorinated aromatic nitrile compound with the molecular formula C7H2ClF2N. This versatile intermediate features a chloro and two fluoro substituents on the benzene ring, offering unique reactivity for nucleophilic aromatic substitution and cross-coupling reactions. With a molecular weight of 173.55 g/mol, this white to off-white crystalline solid is ideal for pharmaceutical synthesis, agrochemical development, and advanced material applications. Packaged under inert gas to ensure stability, our product is rigorously tested by HPLC/GC to guarantee ≥98% purity. Suitable for research scale to kilo-lab production, it is supplied in amber glass bottles with PTFE-lined caps to prevent moisture absorption.

Properties

  • CAS Number: 135748-35-5
  • Complexity: 188
  • IUPAC Name: 4-chloro-2,5-difluoro-benzonitrile
  • InChI: InChI=1S/C7H2ClF2N/c8-5-2-6(9)4(3-11)1-7(5)10/h1-2H
  • InChI Key: OMVDTUXOHXQKML-UHFFFAOYSA-N
  • Exact Mass: 172.9843831
  • Molecular Formula: C7H2ClF2N
  • Molecular Weight: 173.55
  • SMILES: C1=C(C(=CC(=C1F)Cl)F)C#N
  • Topological: 23.8
  • Monoisotopic Mass: 172.9843831
  • Synonyms: 4-CHLORO-2,5-DIFLUOROBENZONITRILE, 135748-35-5, DTXSID10460818, DTXCID00411637, Benzonitrile, 4-chloro-2,5-difluoro-, MFCD06659464, 4-chloro-2,5-difluoro-benzonitrile, SCHEMBL1880028, OMVDTUXOHXQKML-UHFFFAOYSA-N, 2,5-Difluoro-4-chlorobenzonitrile, BCP06184, 2,5-difluoro-4-chloro-benzonitrile, AC-228, CL8209, AKOS006294608, DS-14146, SY111621, DB-005343, CS-0063913, EN300-3256112, Z1198169530

Application

4-Chloro-2,5-difluorobenzonitrile serves as a key building block in Suzuki-Miyaura couplings for creating biaryl structures in drug discovery. The compound’s fluorine atoms enable selective functionalization in the synthesis of kinase inhibitors and antimicrobial agents. Its electron-withdrawing properties make it valuable for developing liquid crystals and OLED materials.

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

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Certain molecules may be protected by active patents or regulatory restrictions.

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  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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