Description

4-Chloro-2,5-difluorobenzoic acid (CAS No. 132794-07-1) is a high-purity fluorinated benzoic acid derivative with the molecular formula C₇H₃ClF₂O₂. This compound is a valuable building block in pharmaceutical and agrochemical synthesis, offering unique reactivity due to its strategically positioned chloro and fluoro substituents. The crystalline solid exhibits excellent stability under standard storage conditions, making it ideal for research and industrial applications. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is available in gram to kilogram quantities with customizable packaging options. Suitable for use in cross-coupling reactions, carboxylation processes, and as a precursor for advanced intermediates.

Properties

• CAS Number: 132794-07-1
• Complexity: 188
• IUPAC Name: 4-chloro-2,5-difluoro-benzoic acid
• InChI: InChI=1S/C7H3ClF2O2/c8-4-2-5(9)3(7(11)12)1-6(4)10/h1-2H,(H,11,12)
• InChI Key: PEPCYJSDHYMIFN-UHFFFAOYSA-N
• Exact Mass: 191.9789634
• Molecular Formula: C7H3ClF2O2
• Molecular Weight: 192.55
• SMILES: C1=C(C(=CC(=C1F)Cl)F)C(=O)O
• Topological: 37.3
• Monoisotopic Mass: 191.9789634
• Synonyms: 4-Chloro-2,5-difluorobenzoic acid, 132794-07-1, DTXSID40369825, DTXCID50320861, 626-140-8, 2,5-DIFLUORO-4-CHLOROBENZOIC ACID, Benzoic acid, 4-chloro-2,5-difluoro-, 4-Chloro-2,5-difluorobenzoic acid;, MFCD00077480, 4-Chloro-2,5-difluorobenzoicacid, 4-chloro-2,5-difluoro-benzoic Acid, SCHEMBL223134, PEPCYJSDHYMIFN-UHFFFAOYSA-N, 2,5-difluoro-4-chloro-benzoic acid, 2.5-difluoro-4-chloro-benzoic acid, SBB003617, AKOS005063903, AC-26018, AS-62575, SY016815, 4-Chloro-2,5-difluorobenzoic acid, 98%, DB-042136, CS-0020037, ST50405252, EN300-111403, Z1203161787

Application

4-Chloro-2,5-difluorobenzoic acid serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates. The compound’s unique substitution pattern enables selective functionalization in medicinal chemistry applications. Researchers utilize this material in the development of herbicides and pesticides due to its bioactivity-modifying properties. It also finds use in material science as a precursor for liquid crystal and polymer synthesis.

Safety and Hazards

GHS Hazard Statements

• H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (95.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (95.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.6%)
• Acute Tox. 4 (95.2%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (95.2%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.