Description
4-Chloro-2-methoxypyridine (CAS No. 72141-44-7) is a high-purity heterocyclic compound with the molecular formula C6H6ClNO. This specialized chemical is widely utilized in pharmaceutical synthesis, agrochemical research, and material science due to its reactive chloro and methoxy functional groups. The compound is supplied as a clear to pale-yellow liquid or crystalline solid, with a purity of ≥98% (GC) to ensure optimal performance in demanding applications. Proper storage under inert atmosphere at 2-8°C is recommended to maintain stability. Available in quantities ranging from 1g to 1kg with customizable packaging options, this product is ideal for researchers requiring precise building blocks for complex molecular architectures. MSDS and analytical certificates are provided with each order.
Properties
- CAS Number: 72141-44-7
- Complexity: 89.1
- IUPAC Name: 4-chloro-2-methoxy-pyridine
- InChI: InChI=1S/C6H6ClNO/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3
- InChI Key: WTDUQQXDOAPXAQ-UHFFFAOYSA-N
- Exact Mass: 143.0137915
- Molecular Formula: C6H6ClNO
- Molecular Weight: 143.57
- SMILES: COC1=NC=CC(=C1)Cl
- Topological: 22.1
- Monoisotopic Mass: 143.0137915
- Synonyms: 4-Chloro-2-methoxypyridine, 72141-44-7, DTXSID30627204, DTXCID30577957, 960-182-0, 4-CHLORO-2-METHOXY-PYRIDINE, 2-Methoxy-4-Chloro-Pyridine, MFCD06738656, 2-Methoxy-4-chloropyridine; 4-Chloro-2-methoxypyridine, 2-Methoxy-4-chloropyridine, SCHEMBL676002, SCHEMBL1967214, SCHEMBL4922129, SCHEMBL7051326, SCHEMBL9481270, WTDUQQXDOAPXAQ-UHFFFAOYSA-N, AKOS006346551, AB27571, CS-W019075, GS-5843, AC-33371, SY022137, DB-006176, EN300-97314, Z1201623697
Application
4-Chloro-2-methoxypyridine serves as a versatile intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer agents. Its electron-deficient pyridine ring facilitates nucleophilic aromatic substitution reactions in medicinal chemistry workflows. The compound is also employed in ligand design for catalytic systems and as a precursor for functionalized pyridine derivatives in material science applications.
Safety and Hazards
GHS Hazard Statements
- H227 (100%): Combustible liquid [Warning Flammable liquids]
- H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
- H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
- H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
- H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statements
- P210, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, and P501
Hazard Classes and Categories
- Flam. Liq. 4 (100%)
- Acute Tox. 4 (100%)
- Skin Irrit. 2 (100%)
- Eye Irrit. 2A (100%)
- STOT SE 3 (100%)
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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.


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