Description

4-Chloro-2-fluoropyridine (CAS No. 34941-92-9) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃ClFN. This heterocyclic compound is a valuable building block in pharmaceutical, agrochemical, and materials science research. Its unique structure, featuring both chloro and fluoro substituents on the pyridine ring, enables precise regioselective modifications in synthetic chemistry applications.

Our product is synthesized under strict quality control measures, ensuring ≥98% purity (GC) with detailed analytical data (NMR, HPLC, MS) available upon request. Supplied in amber glass bottles under inert atmosphere to prevent degradation, it is ideal for nucleophilic substitution reactions, cross-coupling reactions (Suzuki, Stille), and as a precursor for functionalized pyridine scaffolds.

Key Specifications:
– Molecular Weight: 131.54 g/mol
– Boiling Point: 172-174°C (lit.)
– Density: 1.348 g/cm³
– Storage: 2-8°C under nitrogen
– Hazard Codes: Xn (Harmful)

Properties

• CAS Number: 34941-92-9
• Complexity: 78.8
• IUPAC Name: 4-chloro-2-fluoro-pyridine
• InChI: InChI=1S/C5H3ClFN/c6-4-1-2-8-5(7)3-4/h1-3H
• InChI Key: GNJKJKBURMCLOR-UHFFFAOYSA-N
• Exact Mass: 130.9938050
• Molecular Formula: C5H3ClFN
• Molecular Weight: 131.53
• SMILES: C1=CN=C(C=C1Cl)F
• Topological: 12.9
• Monoisotopic Mass: 130.9938050
• Synonyms: 4-chloro-2-fluoropyridine, 34941-92-9, DTXSID50376500, DTXCID60327528, 894-777-0, 2-Fluoro-4-chloropyridine, MFCD04112503, 4-chloro-2-fluoro-pyridine, SCHEMBL1886851, SCHEMBL2244494, SCHEMBL4918823, GNJKJKBURMCLOR-UHFFFAOYSA-N, SBB054331, AKOS005145730, AB17564, AC-6270, CS-W019166, BL006191, DS-10571, SY009424, DB-028794, EN300-127343

Application

4-Chloro-2-fluoropyridine serves as a versatile intermediate in medicinal chemistry for developing kinase inhibitors and CNS-active compounds. The fluorine atom enhances binding affinity to biological targets while the chlorine enables further functionalization via palladium-catalyzed couplings. In material science, it’s used to synthesize liquid crystals and electron-deficient π-conjugated systems for organic electronics. The compound’s orthogonal reactivity makes it particularly valuable for sequential derivatization in combinatorial chemistry approaches.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.