Description

Description

4-Chloro-2-fluoropyridine (CAS No. 34941-92-9) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃ClFN. This heterocyclic compound is a valuable building block in pharmaceutical, agrochemical, and materials science research. Its unique structure, featuring both chloro and fluoro substituents on the pyridine ring, enables precise regioselective modifications in synthetic chemistry applications.

Our product is synthesized under strict quality control measures, ensuring ??98% purity (GC) with detailed analytical data (NMR, HPLC, MS) available upon request. Supplied in amber glass bottles under inert atmosphere to prevent degradation, it is ideal for nucleophilic substitution reactions, cross-coupling reactions (Suzuki, Stille), and as a precursor for functionalized pyridine scaffolds.

Key Specifications:
– Molecular Weight: 131.54 g/mol
– Boiling Point: 172-174??C (lit.)
– Density: 1.348 g/cm³
– Storage: 2-8??C under nitrogen
– Hazard Codes: Xn (Harmful)

Application

4-Chloro-2-fluoropyridine serves as a versatile intermediate in medicinal chemistry for developing kinase inhibitors and CNS-active compounds. The fluorine atom enhances binding affinity to biological targets while the chlorine enables further functionalization via palladium-catalyzed couplings. In material science, it’s used to synthesize liquid crystals and electron-deficient ??-conjugated systems for organic electronics. The compound’s orthogonal reactivity makes it particularly valuable for sequential derivatization in combinatorial chemistry approaches.

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