Description

(4-Chloro-2-fluorophenyl)methanol (CAS: 56456-49-6) is a high-purity aromatic alcohol derivative with the molecular formula C₇H₆ClFO. This compound features a chloro-fluorophenyl backbone with a hydroxymethyl functional group, making it a versatile intermediate in organic synthesis and pharmaceutical research. Its molecular weight of 160.57 g/mol and precise structural configuration ensure consistent reactivity in nucleophilic substitutions, esterifications, and other key transformations. Ideal for researchers requiring a stable, halogenated benzyl alcohol precursor, this product is rigorously tested for purity (typically ≥95% by GC/HPLC) and is supplied in sealed containers to prevent degradation. Store in a cool, dry place under inert conditions to maintain optimal stability.

Properties

• CAS Number: 56456-49-6
• Complexity: 110
• IUPAC Name: (4-chloro-2-fluoro-phenyl)methanol
• InChI: InChI=1S/C7H6ClFO/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2
• InChI Key: XUZRWKWJKDCQNA-UHFFFAOYSA-N
• Exact Mass: 160.0091207
• Molecular Formula: C7H6ClFO
• Molecular Weight: 160.57
• SMILES: C1=CC(=C(C=C1Cl)F)CO
• Topological: 20.2
• Monoisotopic Mass: 160.0091207
• Synonyms: (4-chloro-2-fluorophenyl)methanol, 671-284-7, 4-Chloro-2-fluorobenzyl alcohol, 56456-49-6, 4-Chloro-2-fluorobenzylalcohol, (4-chloro-2-fluoro-phenyl)methanol, MFCD00143285, (4-chloro-2-fluorophenyl)methan-1-ol, Benzenemethanol, 4-chloro-2-fluoro-, Benzenemethanol,4-chloro-2-fluoro-, SCHEMBL134961, SCHEMBL4331373, DTXSID20378591, XUZRWKWJKDCQNA-UHFFFAOYSA-N, BCP24599, SBB087481, AKOS009159513, CS-W002423, AS-19456, SY032819, DB-001288, ST51041694, EN300-1968529

Application

(4-Chloro-2-fluorophenyl)methanol is widely used as a building block in the synthesis of agrochemicals, pharmaceuticals, and specialty chemicals. Its halogenated aromatic structure lends itself to cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig aminations, for creating complex bioactive molecules. Researchers also employ it in the development of fluorinated liquid crystals and polymer modifiers due to its polar functional group and steric properties.

Safety and Hazards

GHS Hazard Statements

• H301 (25%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (25%)
• Skin Irrit. 2 (75%)
• Eye Irrit. 2 (75%)
• STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.