Description

4-Chloro-2-fluoroanisole (CAS No. 452-09-5) is a high-purity aromatic ether compound with the molecular formula C₇H₆ClFO. This versatile intermediate is widely used in pharmaceutical, agrochemical, and material science research due to its unique halogen-substituted anisole structure. Our product is available at 98% purity, ensuring exceptional quality for synthetic applications. The compound features a chloro group at the 4-position and a fluoro group at the 2-position of the methoxy-substituted benzene ring, offering selective reactivity for cross-coupling reactions, nucleophilic substitutions, and other transformations. Suitable for laboratory-scale synthesis and industrial R&D, this reagent is supplied in rigorously tested packaging to guarantee stability and shelf life. Key identifiers include MFCD00672964, NSC-10330, and DTXSID60278849.

Properties

• CAS Number: 452-09-5
• Complexity: 110
• IUPAC Name: 4-chloro-2-fluoro-1-methoxy-benzene
• InChI: InChI=1S/C7H6ClFO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,1H3
• InChI Key: QIUCVZDNIUACJN-UHFFFAOYSA-N
• Exact Mass: 160.0091207
• Molecular Formula: C7H6ClFO
• Molecular Weight: 160.57
• SMILES: COC1=C(C=C(C=C1)Cl)F
• Topological: 9.2
• Monoisotopic Mass: 160.0091207
• Synonyms: 4-Chloro-2-fluoroanisole, 452-09-5, 4-Chloro-2-fluoro-1-methoxybenzene, DTXSID60278849, DTXCID80230005, 625-001-9, 4-CHLORO-2-FLUORO-1-METHOXY-BENZENE, Benzene, 4-chloro-2-fluoro-1-methoxy-, Anisole, 4-chloro-2-fluoro-, MFCD00672964, NSC-10330, NSC10330, Chlor-4 Methoxy-5 Fluorbenzol, SCHEMBL1762042, SCHEMBL1765256, SCHEMBL2347534, SCHEMBL2353746, SCHEMBL3754064, 4-Chloro-2-fluoroanisole, 98%, 727D82AC8X, 1-Chloro-3-fluoro-4-methoxybenzene, SBB087482, AKOS015889951, 4-Chloro-2-fluoro-1-methoxybenzene #, JS-4297, AC-25973, CS-0159916, ST51038387, N12152

4-Chloro-2-fluoroanisole serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. It is particularly valuable in Suzuki-Miyaura coupling reactions to create biaryl structures for drug discovery. The compound’s electron-withdrawing halogen groups enhance its utility in nucleophilic aromatic substitution (S_NAr) reactions. Researchers also employ it in agrochemical development for crop protection agents. Its stability under various conditions makes it ideal for multi-step synthetic routes.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.