Description

4-Chloro-2-fluoroaniline (CAS No. 57946-56-2) is a high-purity organic compound with the molecular formula C₆H₅ClFN. This halogenated aniline derivative is widely used in pharmaceutical, agrochemical, and material science research due to its versatile reactivity as an intermediate. Our product is rigorously tested to ensure a purity of ≥98%, making it ideal for synthetic applications requiring precise stoichiometry. Suitable for laboratory and industrial-scale use, it is supplied in secure, chemically resistant packaging to maintain stability. MSDS and analytical certificates (CoA) are available upon request to ensure compliance with safety and regulatory standards.

Properties

• CAS Number: 57946-56-2
• Complexity: 99.1
• IUPAC Name: 4-chloro-2-fluoro-aniline
• InChI: InChI=1S/C6H5ClFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
• InChI Key: CSFDTBRRIBJILD-UHFFFAOYSA-N
• Exact Mass: 145.0094550
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.56
• SMILES: C1=CC(=C(C=C1Cl)F)N
• Topological: 26
• Monoisotopic Mass: 145.0094550
• Synonyms: 4-Chloro-2-fluoroaniline, 57946-56-2, EINECS 261-034-1, DTXSID00206666, DTXCID30129157, 261-034-1, 2-fluoro-4-chloroaniline, 4-chloro-2-fluorobenzenamine, 4-Chloro-2-fluoro-phenylamine, Benzenamine, 4-chloro-2-fluoro-, 4-chloro-2-fluoro-aniline, MFCD00010625, 4-chloro-2-fluorophenylamine, 2-fluoro-4-chloro-aniline, 4-Chloro-2-fluorobenzenamine; 2-Fluoro-4-chloroaniline; 4-Chloro-2-fluorophenylamine;, 4chloro-2-fluoroaniline, SCHEMBL112519, SCHEMBL905589, SCHEMBL9385771, 4-chloranyl-2-fluoranyl-aniline, SCHEMBL27293852, SCHEMBL28030269, 4-Chloro-2-fluoroaniline, 98%, SBB004111, STL169020, AKOS000113481, AC-3668, CCG-302537, CS-W014353, FC64319, PS-8957, DB-024143, NS00053588, ST50307123, EN300-20292, A831681, F0001-1510, Z104477618, InChI=1/C6H5ClFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H

4-Chloro-2-fluoroaniline serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. Its reactive amino and halogen groups enable coupling reactions, such as Buchwald-Hartwig amination or nucleophilic aromatic substitution. Researchers also utilize it to develop fluorescent dyes and liquid crystal materials. Handle with appropriate PPE due to potential toxicity.

Safety and Hazards

GHS Hazard Statements

• H302 (95.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (10.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H312 (89.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (97.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (89.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (12.8%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (95.7%)
• Acute Tox. 3 (10.6%)
• Acute Tox. 4 (89.4%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (97.9%)
• STOT SE 3 (89.4%)
• STOT RE 2 (12.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.