Description

4-Bromopyridine-2-carboxylic acid (CAS No. 30766-03-1) is a high-purity brominated pyridine derivative with the molecular formula C₆H₄BrNO₂. This compound serves as a versatile building block in pharmaceutical synthesis, agrochemical development, and advanced material research. Its carboxylic acid functional group and bromine substitution at the 4-position make it an ideal intermediate for cross-coupling reactions, metal-catalyzed transformations, and heterocyclic chemistry. Our product is rigorously tested to ensure ≥98% purity (HPLC), with comprehensive analytical data including ¹H NMR, ¹³C NMR, and mass spectrometry available upon request. Supplied as a white to off-white crystalline powder with excellent shelf stability when stored at 2-8°C in airtight containers. Suitable for medicinal chemistry applications, catalyst development, and as a precursor for liquid crystal materials.

Properties

• CAS Number: 30766-03-1
• Complexity: 140
• IUPAC Name: 4-bromopyridine-2-carboxylic acid
• InChI: InChI=1S/C6H4BrNO2/c7-4-1-2-8-5(3-4)6(9)10/h1-3H,(H,9,10)
• InChI Key: RPHHYRNGCJYQSP-UHFFFAOYSA-N
• Exact Mass: 200.94254
• Molecular Formula: C6H4BrNO2
• Molecular Weight: 202.01
• SMILES: C1=CN=C(C=C1Br)C(=O)O
• Topological: 50.2
• Monoisotopic Mass: 200.94254
• Synonyms: 4-bromopyridine-2-carboxylic acid, 30766-03-1, DTXSID30352741, DTXCID00303806, 676-387-0, 4-Bromopicolinic acid, 4-Bromo-2-pyridinecarboxylic acid, 2-Pyridinecarboxylic acid, 4-bromo-, 4-Bromo-pyridine-2-carboxylic acid, MFCD03426665, F1926-0016, SMSSF-0044122, 4-Bromopicolinicacid, AF-399/41061033, MLS000685975, SCHEMBL100727, CHEMBL1472469, RPHHYRNGCJYQSP-UHFFFAOYSA-N, HMS2592A16, BBL100138, SBB016176, STL224109, AKOS000270390, AC-2608, CS-W004860, FB13009, HY-W004860, PB21234, PS-5448, SMR000324845, SY002817, DB-028772, B4041, ST45174497, EN300-53478, B67456, A1-31480, Z802558860, 4-Bromopicolinic acid, 4-Bromopyridine-2-Carboxylic Acid, 4-Bromopicolinic acid; 4-Bromo-2-pyridinecarboxylic Acid

4-Bromopyridine-2-carboxylic acid is widely employed as a key synthon in Suzuki-Miyaura and Negishi coupling reactions for pharmaceutical intermediates. The compound serves as a crucial precursor in the synthesis of kinase inhibitors and other bioactive molecules targeting neurological disorders. Researchers utilize its reactive sites for constructing complex heterocyclic systems through palladium-catalyzed transformations. In material science, it functions as a building block for electron-transport materials in organic electronics. The bromine substituent enables efficient functionalization while the carboxylic acid group facilitates further derivatization through amidation or esterification.

Safety and Hazards

GHS Hazard Statements

• H302+H312+H332 (16.7%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (16.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (16.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (83.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (83.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (16.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (16.7%)
• Acute Tox. 4 (16.7%)
• Skin Irrit. 2 (83.3%)
• Eye Irrit. 2 (83.3%)
• Acute Tox. 4 (16.7%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.