Description

4-(Bromomethyl)-1,2-difluorobenzene (CAS No. 85118-01-0) is a high-purity organic compound with the molecular formula C₇H₅BrF₂. This versatile reagent is widely used in pharmaceutical and agrochemical synthesis, serving as a key intermediate in the preparation of complex fluorinated molecules. Its unique structure, featuring a reactive bromomethyl group and two fluorine atoms on the aromatic ring, makes it particularly valuable for nucleophilic substitution reactions and cross-coupling chemistry. Our product is rigorously tested to ensure >98% purity (GC) and is supplied in sealed containers under inert atmosphere to maintain stability. Available in quantities from grams to kilograms, this compound is ideal for research laboratories and industrial applications requiring precise fluorinated building blocks.

Properties

• CAS Number: 85118-01-0
• Complexity: 108
• IUPAC Name: 4-(bromomethyl)-1,2-difluoro-benzene
• InChI: InChI=1S/C7H5BrF2/c8-4-5-1-2-6(9)7(10)3-5/h1-3H,4H2
• InChI Key: JJIFTOPVKWDHJI-UHFFFAOYSA-N
• Exact Mass: 205.95427
• Molecular Formula: C7H5BrF2
• Molecular Weight: 207.01
• SMILES: C1=CC(=C(C=C1CBr)F)F
• Monoisotopic Mass: 205.95427
• Synonyms: 3,4-Difluorobenzyl bromide, 85118-01-0, 4-(Bromomethyl)-1,2-difluorobenzene, EINECS 285-653-1, DTXSID70234239, DTXCID20156730, 285-653-1, 3,4-difluorobenzylbromide, alpha-Bromo-3,4-difluorotoluene, Benzene, 4-(bromomethyl)-1,2-difluoro-, MFCD00009889, 4-bromomethyl-1,2-difluorobenzene, 3, 4-difluorobenzyl bromide, 4-(bromomethyl)-1,2-difluoro-benzene, 3,4 difluorobenzyl bromide, 3,4-difluoro-benzylbromide, 3,4-difluro benzyl bromide, 3,4-di-fluorobenzyl bromide, 3,4-difluoro-benzyl bromide, SCHEMBL118519, 1-bromomethyl-3,4-difluorobenzene, 3,4-Difluorobenzyl bromide, 98%, .alpha.-Bromo-3,4-difluorotoluene, SBB006563, AKOS000123044, AC-9738, 4-(Bromomethyl)-1,2-difluorobenzene #, AS-14508, DB-024269, D2627, NS00066344, ST51039989, EN300-12402, F2190-0299

4-(Bromomethyl)-1,2-difluorobenzene is primarily employed as a fluorinated benzylating agent in pharmaceutical synthesis. It serves as a key intermediate in the production of active pharmaceutical ingredients (APIs) with enhanced metabolic stability due to fluorine substitution. The compound is particularly valuable in medicinal chemistry for creating CNS-targeting molecules and kinase inhibitors. Its reactivity also makes it useful in material science for synthesizing fluorinated liquid crystals and polymers.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H335 (85.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• STOT SE 3 (85.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.