Description

4-Bromobenzoyl chloride (CAS 586-75-4) is a high-purity organic compound with the molecular formula C₇H₄BrClO. This aromatic acyl chloride is a versatile reagent widely used in organic synthesis, pharmaceutical research, and material science applications. The compound features a reactive benzoyl chloride group para-substituted with a bromine atom, making it a valuable building block for nucleophilic substitution and cross-coupling reactions. Our product is rigorously tested to ensure exceptional quality, with typical purity ≥98% (GC) and proper storage under inert atmosphere to maintain stability. Offered in convenient packaging options ranging from 1g to 1kg, this moisture-sensitive compound should be handled under anhydrous conditions. The technical specifications include: molecular weight 219.46 g/mol, density 1.647 g/cm³, boiling point 230-232°C, and melting point 19-21°C. Suitable for use in peptide coupling reactions, Suzuki couplings, and as a precursor for liquid crystal materials.

Properties

• CAS Number: 586-75-4
• Complexity: 130
• IUPAC Name: 4-bromobenzoyl chloride
• InChI: InChI=1S/C7H4BrClO/c8-6-3-1-5(2-4-6)7(9)10/h1-4H
• InChI Key: DENKGPBHLYFNGK-UHFFFAOYSA-N
• Exact Mass: 217.91341
• Molecular Formula: C7H4BrClO
• Molecular Weight: 219.46
• SMILES: C1=CC(=CC=C1C(=O)Cl)Br
• Topological: 17.1
• Monoisotopic Mass: 217.91341
• Synonyms: 4-Bromobenzoyl chloride, Benzoyl chloride, 4-bromo-, NSC 7091, EINECS 209-580-1, DTXSID2060412, DTXCID7042439, 209-580-1, denkgpbhlyfngk-uhfffaoysa-n, 586-75-4, p-Bromobenzoyl chloride, 4-Bromobenzoylchloride, Benzoyl chloride, p-bromo-, p-Bromobenzoyl chloride, p-bromo-, 4-bromo-benzoyl chloride, MFCD00000683, NSC-7091, 4-bromobenzoic acid chloride, p-Brombenzoylchlorid, 4bromobenzoyl chloride, p-BrC6H4COCl, 4-bromo-benzoylchloride, 4-bromobenzoyl-chloride, parabromobenzoyl chloride, rho-bromobenzoyl chloride, 4-bromo-benzoyl-chloride, 4-Bromo benzoyl chloride, SCHEMBL1088, W72HA95JJC, 4-Bromobenzoyl chloride, 98%, NSC7091, 4-Bromo-1-benzenecarbonyl chloride, SBB058718, AKOS009031172, FB10832, PS-10792, DB-006726, B0558, NS00033992, ST50214066, EN300-21294, A831975, p-Bromobenzoyl Chloride; 4-Bromo-1-benzenecarbonyl Chloride; 4-Bromobenzoyl Chloride; NSC 7091; p-Bromobenzoyl Chloride

Application

4-Bromobenzoyl chloride serves as a key intermediate in pharmaceutical synthesis, particularly for creating brominated aromatic compounds. Researchers utilize this reagent for introducing the 4-bromobenzoyl moiety in medicinal chemistry projects and material science applications. The compound finds particular use in palladium-catalyzed cross-coupling reactions and as a precursor for liquid crystal materials. Its dual functionality makes it valuable for both nucleophilic acyl substitution and electrophilic aromatic substitution pathways.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H335 (25%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• STOT SE 3 (25%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.