Description

4′-Bromo-4-ethoxy-2,3-difluoro-1,1′-biphenyl (CAS No. 470461-09-7) is a high-purity, halogenated biphenyl derivative with the molecular formula C₁₄H₁₁BrF₂O. This compound features a bromine substituent on the para position of one phenyl ring and an ethoxy group with adjacent fluorine atoms on the second phenyl ring, offering unique electronic and steric properties for advanced synthetic applications. It is supplied as a crystalline solid with ≥95% purity (HPLC), ideal for use as a key intermediate in pharmaceutical research, material science, and ligand design. The compound’s structural motif is valuable for Suzuki coupling reactions, liquid crystal development, and as a precursor for fluorinated organic electronic materials. Proper storage under inert conditions is recommended to maintain stability.

Properties

• CAS Number: 470461-09-7
• Complexity: 256
• IUPAC Name: 1-(4-bromophenyl)-4-ethoxy-2,3-difluoro-benzene
• InChI: InChI=1S/C14H11BrF2O/c1-2-18-12-8-7-11(13(16)14(12)17)9-3-5-10(15)6-4-9/h3-8H,2H2,1H3
• InChI Key: VFNYZNWPLITFPE-UHFFFAOYSA-N
• Exact Mass: 311.99613
• Molecular Formula: C14H11BrF2O
• Molecular Weight: 313.14
• SMILES: CCOC1=C(C(=C(C=C1)C2=CC=C(C=C2)Br)F)F
• Topological: 9.2
• Monoisotopic Mass: 311.99613
• Synonyms: 4′-Bromo-4-ethoxy-2,3-difluoro-1,1′-biphenyl, 470461-09-7, 1-(4-bromophenyl)-4-ethoxy-2,3-difluorobenzene, MFCD25460355, 4-ethoxy-4′-bromo-2,3-difluoro-1,1′-biphenyl, SCHEMBL1242253, VFNYZNWPLITFPE-UHFFFAOYSA-N, AKOS024438252, AS-33367

Application

4′-Bromo-4-ethoxy-2,3-difluoro-1,1′-biphenyl serves as a versatile building block in organic synthesis, particularly in cross-coupling reactions to construct complex fluorinated biaryl systems. Researchers utilize this compound in the development of liquid crystalline materials due to its rigid, halogenated biphenyl core. It is also employed in medicinal chemistry for the synthesis of fluorinated drug candidates targeting CNS disorders.

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